FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014192866> ?p ?o ?g. }

• W2014192866 endingPage "283" @default.
• W2014192866 startingPage "279" @default.
• W2014192866 abstract "1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) produces Parkinsonism in both experimental animals and in man. MPTP is metabolized to 1-methyl-4-phenylpridinium, an inhibitor of mitochondrial complex I. MPTP administration produces ATP depletions in vivo, which may lead to secondary excitotoxicity and free radical generation. If this is the case then agents which improve mitochondrial function or free radical scavengers should attenuate MPTP neurotoxicity. In the present experiments three regimens of MPTP administration produced varying degrees of striatal dopamine depletion. A combination of coenzyme Q10 and nicotinamide protected against both mild and moderate depletion of dopamine. In the MPTP regimen which produced mild dopamine depletion nicotinamide or the free radical spin trap N-tert-butyl-α-(2-sulfophenyl)-nitrone were also effective. There was no protection with a MPTP regimen which produced severe dopamine depletion. These results show that agents which improve mitochondrial energy production (coenzyme Q10 and nicotinamide) and free radical scavengers can attenuate mild to moderate MPTP neurotoxicity." @default.
• W2014192866 created "2016-06-24" @default.
• W2014192866 creator A5003238248 @default.
• W2014192866 creator A5033794504 @default.
• W2014192866 creator A5057471512 @default.
• W2014192866 creator A5057749582 @default.
• W2014192866 date "1995-04-01" @default.
• W2014192866 modified "2023-09-25" @default.
• W2014192866 title "Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity" @default.
• W2014192866 cites W1965876571 @default.
• W2014192866 cites W1966725395 @default.
• W2014192866 cites W1978639395 @default.
• W2014192866 cites W2005706069 @default.
• W2014192866 cites W2016905315 @default.
• W2014192866 cites W2019271502 @default.
• W2014192866 cites W2019431280 @default.
• W2014192866 cites W2048367257 @default.
• W2014192866 cites W2051681090 @default.
• W2014192866 cites W2052226187 @default.
• W2014192866 cites W2055308573 @default.
• W2014192866 cites W2062833196 @default.
• W2014192866 cites W2085228114 @default.
• W2014192866 cites W2088101905 @default.
• W2014192866 cites W2111065594 @default.
• W2014192866 cites W2111316498 @default.
• W2014192866 cites W2145213346 @default.
• W2014192866 cites W2145302977 @default.
• W2014192866 cites W2149105763 @default.
• W2014192866 cites W2150648464 @default.
• W2014192866 cites W2151323478 @default.
• W2014192866 cites W2158439853 @default.
• W2014192866 cites W2159359085 @default.
• W2014192866 cites W2160690724 @default.
• W2014192866 doi "https://doi.org/10.1016/0014-4886(95)90033-0" @default.
• W2014192866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7789466" @default.
• W2014192866 hasPublicationYear "1995" @default.
• W2014192866 type Work @default.
• W2014192866 sameAs 2014192866 @default.
• W2014192866 citedByCount "101" @default.
• W2014192866 countsByYear W20141928662012 @default.
• W2014192866 countsByYear W20141928662013 @default.
• W2014192866 countsByYear W20141928662014 @default.
• W2014192866 countsByYear W20141928662015 @default.
• W2014192866 countsByYear W20141928662017 @default.
• W2014192866 countsByYear W20141928662018 @default.
• W2014192866 countsByYear W20141928662019 @default.
• W2014192866 countsByYear W20141928662020 @default.
• W2014192866 countsByYear W20141928662022 @default.
• W2014192866 crossrefType "journal-article" @default.
• W2014192866 hasAuthorship W2014192866A5003238248 @default.
• W2014192866 hasAuthorship W2014192866A5033794504 @default.
• W2014192866 hasAuthorship W2014192866A5057471512 @default.
• W2014192866 hasAuthorship W2014192866A5057749582 @default.
• W2014192866 hasConcept C126322002 @default.
• W2014192866 hasConcept C137183658 @default.
• W2014192866 hasConcept C178790620 @default.
• W2014192866 hasConcept C181199279 @default.
• W2014192866 hasConcept C185592680 @default.
• W2014192866 hasConcept C2778674702 @default.
• W2014192866 hasConcept C2779384338 @default.
• W2014192866 hasConcept C2779491297 @default.
• W2014192866 hasConcept C2779728014 @default.
• W2014192866 hasConcept C29730261 @default.
• W2014192866 hasConcept C513476851 @default.
• W2014192866 hasConcept C55493867 @default.
• W2014192866 hasConcept C71924100 @default.
• W2014192866 hasConcept C98274493 @default.
• W2014192866 hasConceptScore W2014192866C126322002 @default.
• W2014192866 hasConceptScore W2014192866C137183658 @default.
• W2014192866 hasConceptScore W2014192866C178790620 @default.
• W2014192866 hasConceptScore W2014192866C181199279 @default.
• W2014192866 hasConceptScore W2014192866C185592680 @default.
• W2014192866 hasConceptScore W2014192866C2778674702 @default.
• W2014192866 hasConceptScore W2014192866C2779384338 @default.
• W2014192866 hasConceptScore W2014192866C2779491297 @default.
• W2014192866 hasConceptScore W2014192866C2779728014 @default.
• W2014192866 hasConceptScore W2014192866C29730261 @default.
• W2014192866 hasConceptScore W2014192866C513476851 @default.
• W2014192866 hasConceptScore W2014192866C55493867 @default.
• W2014192866 hasConceptScore W2014192866C71924100 @default.
• W2014192866 hasConceptScore W2014192866C98274493 @default.
• W2014192866 hasIssue "2" @default.
• W2014192866 hasLocation W20141928661 @default.
• W2014192866 hasLocation W20141928662 @default.
• W2014192866 hasOpenAccess W2014192866 @default.
• W2014192866 hasPrimaryLocation W20141928661 @default.
• W2014192866 hasRelatedWork W1984089943 @default.
• W2014192866 hasRelatedWork W2021695493 @default.
• W2014192866 hasRelatedWork W2025918436 @default.
• W2014192866 hasRelatedWork W2027887708 @default.
• W2014192866 hasRelatedWork W2039035080 @default.
• W2014192866 hasRelatedWork W2073009342 @default.
• W2014192866 hasRelatedWork W2088987210 @default.
• W2014192866 hasRelatedWork W2396474461 @default.
• W2014192866 hasRelatedWork W2579823917 @default.
• W2014192866 hasRelatedWork W3207431744 @default.
• W2014192866 hasVolume "132" @default.
• W2014192866 isParatext "false" @default.

• next