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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014193175> ?p ?o ?g. }

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• W2014193175 abstract "Transcriptional regulation depends on sequence-specific binding of regulatory proteins to their responsive elements in viral DNA. The papillomavirus E2 protein binds to DNA through the consensus sequence ACCG-NNNN-CGGT, activating or inhibiting viral replication. Through molecular dynamics simulations we were able to characterize the role of the DNA molecule on E2 binding region (named alpha(1)E2) conformation, acquiring structural insights for previous works suggesting an unfolded to folded transition upon alpha(1)E2 complexation to DNA. Moreover, the results indicate sites to guide the design of alpha(1)E2 synthetic derivatives to inhibit the HPV infection." @default.
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• W2014193175 date "2008-10-01" @default.
• W2014193175 modified "2023-10-05" @default.
• W2014193175 title "Characterization of the papillomavirus α₁E2 peptide unfolded to folded transition upon DNA binding" @default.
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• W2014193175 doi "https://doi.org/10.1016/j.febslet.2008.09.041" @default.
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