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- W2014193771 abstract "<h2>Abstract</h2> A total of 50 patients with carcinoma of the rectum were treated with 5-fluorouracil suppository before operation. The suppository, which was made of Witepsol suppository base containing 5-fluorouracil, yielded high drug concentrations in carcinoma, draining blood and regional lymph nodes. As a clinical response to the suppository, a significant decrease in the size of tumor mass was noted in 8 of 50 carcinomas, but in other cases the gross change was unmeasurable. Thirty-three percent of the surgically resected carcinomas were histologically judged to have responded to the suppository. In such cases, histologic changes correlated well with the total dose of 5-fluorouracil. The adverse effects of the suppository were confined to anal pain, tenesmus and anal bleeding, probably due to the topical effect of 5-fluorouracil on the rectal mucosa." @default.
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- W2014193771 date "1982-02-01" @default.
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- W2014193771 title "Preoperative use of 5-fluorouracil suppository for carcinoma of the rectum" @default.
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- W2014193771 doi "https://doi.org/10.1016/0002-9610(82)90062-9" @default.
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