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• W2014193944 abstract "A modified form (HK I(+)) of rat Type I hexokinase (HK I) has been expressed. HK I(+) contains a centrally located polyalanine insert which, along with the known helical propensity of adjacent sequence, was expected to lead to alpha-helix formation, with resulting distension of the molecule and disruption of interactions between the N- and C-terminal halves. The properties of HK I(+) are consistent with this expectation and with previous proposals that (1) inhibition of HK I by Glc-6-P or its analogs and antagonism of this inhibition by P(i) result from competition of these ligands for a binding site in the N-terminal half of HK I, with resulting conformational changes propagated through interactions with the catalytic C-terminal half, and (2) binding of Glc-6-P to a site in the C-terminal half of HK I is obstructed by interactions between the halves, present in HK I but not HK I(+)." @default.
• W2014193944 created "2016-06-24" @default.
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• W2014193944 date "2002-03-01" @default.
• W2014193944 modified "2023-10-14" @default.
• W2014193944 title "Kinetic and Regulatory Properties of HK I+, a Modified Form of the Type I Isozyme of Mammalian Hexokinase in Which Interactions between the N- and C-Terminal Halves Have Been Disrupted" @default.
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• W2014193944 doi "https://doi.org/10.1006/abbi.2001.2744" @default.
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