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• W2014194295 abstract "Posttraumatic stress disorder (PTSD) is a debilitating disease, which affects 8–10% of the population exposed to traumatic events. The factors that make certain individuals susceptible to PTSD and others resilient are currently unknown. Corticotropin-releasing factor receptor type 2 (CRFR2) has been implicated in mediating stress coping mechanisms. Here, we use a physiological PTSD-like animal model and an in-depth battery of tests that reflect the symptomology of PTSD to separate mice into subpopulations of “PTSD-like” and “Resilient” phenotypes. PTSD-like mice are hypervigilant, hyperalert, insomniac, have impaired attention and risk assessment, as well as accompanying attenuated corticosterone levels. Intriguingly, PTSD-like mice show long-term robust upregulation of BNST-CRFR2 mRNA levels, and BNST-CRFR2-specific lentiviral knockdown reduces susceptibility to PTSD-like behavior. Additionally, using a BNST mRNA expression array, PTSD-like mice exhibit a general transcriptional attenuation profile, which was associated with upregulation of the BNST-deacetylation enzyme, HDAC5. We suggest PTSD to be a disease of maladaptive coping." @default.
• W2014194295 created "2016-06-24" @default.
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• W2014194295 date "2012-05-16" @default.
• W2014194295 modified "2023-10-14" @default.
• W2014194295 title "Susceptibility to PTSD-Like Behavior Is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis" @default.
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• W2014194295 doi "https://doi.org/10.1523/jneurosci.4012-11.2012" @default.
• W2014194295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6622202" @default.
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