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- W2014194311 abstract "RATIONALE: S. pneumoniae is the most common cause of community acquired respiratory tract infections. IFNγ is an important cytokine in controlling immune responses. Our studies show that neutrophils recruited to acute pneumococcal pneumonias produce IFNγ and that IFNγ is important in bacterial clearance. Nos2, Cxcl11, Cxcr2 and Ccr5 are important in host defense and known to be regulated by IFNγ. We postulated that S. pneumoniae-induced expression of these genes is altered in IFNγ-deficient (Ifng-/-) mice. METHODS: WT and Ifng-/- mice were given PBS (n=4 mice per group) or S. pneumoniae (4.30 ± 0.42 x 106, n=5) by intratracheal inoculation. After 24 hours, mRNA levels of Nos2, Cxcl11, Cxcr2 and Ccr5 were measured in lung tissue using real time RT-PCR. RESULTS: Nos2, Cxcl11, Cxcr2 and Ccr5 mRNAs were induced ∼4-60 fold in S. pneumoniae infected lungs compared to PBS-treated controls (p<0.05 Kruskal-Wallis with Dunn's test for multiple comparisons). In contrast, none were significantly increased in Ifng -/- mice. However, due to high variability in values for Ifng-/- mice with pneumonia, there was no significant difference in Ifng-/- compared to WT mice. The role of IFNγ was most clear for Nos2; WT mice had an 32 fold increase in Nos2 mRNA, whereas Ifng-/- showed only a 2.4 fold increase. CONCLUSIONS: The defect in clearance of S. pneumoniae in Ifng-/- mice is most likely due to a partial effect on gene transcription of multiple genes. For example, Nos2 is an important enzyme producing nitric oxide, which has antimicrobial properties and may contribute to control of these infections." @default.
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- W2014194311 date "2011-02-01" @default.
- W2014194311 modified "2023-09-26" @default.
- W2014194311 title "Neutrophil-derived Interferon γ (IFNγ) Controls Inducible Nitric Oxide Synthase (Nos2) During Pneumococcal Pneumonia" @default.
- W2014194311 doi "https://doi.org/10.1016/j.jaci.2010.12.392" @default.
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