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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014194472> ?p ?o ?g. }

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• W2014194472 abstract "How tyrosine kinases of the Src family regulate platelet-derived growth factor (PDGF)-induced DNA synthesis remains elusive. Here we show that the E1A antigen of adenovirus 5 overrides the G1 block elicited by the kinase-inactive mutant SrcK(-). This was dependent upon the CR2 region of E1A that upregulated cyclin E and cyclin A and inactivated the pocket protein pRb. E1A rescue was independent of pRb. Expression of SrcK(-) in fibroblasts prevented PDGF-induced expression of cyclins E and A. This effect was overcome by E1A. Constitutive expression of cyclins E and A, but not D1, restored mitogenesis that was inhibited by SrcK(-). We conclude that both cyclin E and cyclin A are likely targets of Src mediating PDGF-induced DNA synthesis." @default.
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• W2014194472 date "2002-08-01" @default.
• W2014194472 modified "2023-10-18" @default.
• W2014194472 title "Cyclin E and cyclin A are likely targets of Src for PDGF-induced DNA synthesis in fibroblasts" @default.
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• W2014194472 doi "https://doi.org/10.1016/s0014-5793(02)03120-4" @default.
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