FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014198003> ?p ?o ?g. }

• W2014198003 endingPage "1629" @default.
• W2014198003 startingPage "1618" @default.
• W2014198003 abstract "Human gene 3 relaxin (H3 relaxin) is a member of the relaxin/insulin family of peptides. Neuropeptides mediate behavioral responses to stress and regulates appetite; however, the cell signaling mechanisms that control these events remain to be identified. The relaxin family peptide receptor 3 (RXFP3, formerly GPCR135 or SALPR) was characterized as the receptor for H3 relaxin, functionally coupled to the inhibition of cAMP. We have identified that RXFP3 stably expressed in Chinese hamster ovary (CHO)-K1 (CHO-RXFP3) and human embryonic kidney (HEK) 293 (HEK-RXFP3) cells activates extracellular signal-regulated kinase (ERK) 1/2 when stimulated with H3 relaxin and an H3 relaxin B-chain (dimer) peptide. Using inhibitors of cellular signaling proteins, we subsequently determined the mechanism of ERK1/2 activation by RXFP3. ERK1/2 phosphorylation requires the activation of G_i/o proteins and seems to require receptor internalization and/or compartmentalization into lipid-rich environments. ERK1/2 activation also predominantly occurred via the activation of a protein kinase C-dependent pathway, although activation of phosphatidylinositol 3-kinase and Src tyrosine kinase were also involved to a lesser extent. The mechanisms underlying ERK1/2 phosphorylation were similar in both CHO-RXFP3 and HEK-RXFP3 cells, although some differences were evident. Phospholipase Cβ and the transactivation of endogenous epidermal growth factor receptors both played a role in RXFP3-mediated ERK1/2 activation in HEK293 cells; however, they were not involved in RXFP3-mediated ERK1/2 activation in the CHO-K1 cell background. The pathways identified in CHO- and HEK-transfected cells were also used in the murine SN56 neuronal cell line, suggesting that these pathways are also important for RXFP3-mediated signaling in the brain." @default.
• W2014198003 created "2016-06-24" @default.
• W2014198003 creator A5021082373 @default.
• W2014198003 creator A5039280859 @default.
• W2014198003 creator A5055703629 @default.
• W2014198003 creator A5075463548 @default.
• W2014198003 date "2007-03-09" @default.
• W2014198003 modified "2023-09-25" @default.
• W2014198003 title "The Relaxin Family Peptide Receptor 3 Activates Extracellular Signal-Regulated Kinase 1/2 through a Protein Kinase C-Dependent Mechanism" @default.
• W2014198003 cites W1614576580 @default.
• W2014198003 cites W1695992398 @default.
• W2014198003 cites W1755018410 @default.
• W2014198003 cites W1968625794 @default.
• W2014198003 cites W1972262775 @default.
• W2014198003 cites W1976252854 @default.
• W2014198003 cites W1983020843 @default.
• W2014198003 cites W1987852700 @default.
• W2014198003 cites W1992205234 @default.
• W2014198003 cites W1999592998 @default.
• W2014198003 cites W2000110544 @default.
• W2014198003 cites W2001626986 @default.
• W2014198003 cites W2010709434 @default.
• W2014198003 cites W2011118970 @default.
• W2014198003 cites W2011403383 @default.
• W2014198003 cites W2012416101 @default.
• W2014198003 cites W2017958259 @default.
• W2014198003 cites W2018332833 @default.
• W2014198003 cites W2022325110 @default.
• W2014198003 cites W2034825884 @default.
• W2014198003 cites W2049081582 @default.
• W2014198003 cites W2052750950 @default.
• W2014198003 cites W2054170086 @default.
• W2014198003 cites W2058525665 @default.
• W2014198003 cites W2067286058 @default.
• W2014198003 cites W2067321086 @default.
• W2014198003 cites W2078381702 @default.
• W2014198003 cites W2078826554 @default.
• W2014198003 cites W2085557924 @default.
• W2014198003 cites W2109786659 @default.
• W2014198003 cites W2116005796 @default.
• W2014198003 cites W2120072474 @default.
• W2014198003 cites W2125686850 @default.
• W2014198003 cites W2132468662 @default.
• W2014198003 cites W2140424595 @default.
• W2014198003 cites W2152975936 @default.
• W2014198003 cites W2156228214 @default.
• W2014198003 cites W2156437245 @default.
• W2014198003 doi "https://doi.org/10.1124/mol.106.032763" @default.
• W2014198003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17351017" @default.
• W2014198003 hasPublicationYear "2007" @default.
• W2014198003 type Work @default.
• W2014198003 sameAs 2014198003 @default.
• W2014198003 citedByCount "77" @default.
• W2014198003 countsByYear W20141980032012 @default.
• W2014198003 countsByYear W20141980032013 @default.
• W2014198003 countsByYear W20141980032014 @default.
• W2014198003 countsByYear W20141980032015 @default.
• W2014198003 countsByYear W20141980032016 @default.
• W2014198003 countsByYear W20141980032017 @default.
• W2014198003 countsByYear W20141980032018 @default.
• W2014198003 countsByYear W20141980032019 @default.
• W2014198003 countsByYear W20141980032020 @default.
• W2014198003 countsByYear W20141980032021 @default.
• W2014198003 countsByYear W20141980032022 @default.
• W2014198003 crossrefType "journal-article" @default.
• W2014198003 hasAuthorship W2014198003A5021082373 @default.
• W2014198003 hasAuthorship W2014198003A5039280859 @default.
• W2014198003 hasAuthorship W2014198003A5055703629 @default.
• W2014198003 hasAuthorship W2014198003A5075463548 @default.
• W2014198003 hasConcept C170493617 @default.
• W2014198003 hasConcept C174510640 @default.
• W2014198003 hasConcept C175656101 @default.
• W2014198003 hasConcept C184235292 @default.
• W2014198003 hasConcept C2777121736 @default.
• W2014198003 hasConcept C55493867 @default.
• W2014198003 hasConcept C57074206 @default.
• W2014198003 hasConcept C62478195 @default.
• W2014198003 hasConcept C86803240 @default.
• W2014198003 hasConcept C95444343 @default.
• W2014198003 hasConceptScore W2014198003C170493617 @default.
• W2014198003 hasConceptScore W2014198003C174510640 @default.
• W2014198003 hasConceptScore W2014198003C175656101 @default.
• W2014198003 hasConceptScore W2014198003C184235292 @default.
• W2014198003 hasConceptScore W2014198003C2777121736 @default.
• W2014198003 hasConceptScore W2014198003C55493867 @default.
• W2014198003 hasConceptScore W2014198003C57074206 @default.
• W2014198003 hasConceptScore W2014198003C62478195 @default.
• W2014198003 hasConceptScore W2014198003C86803240 @default.
• W2014198003 hasConceptScore W2014198003C95444343 @default.
• W2014198003 hasIssue "6" @default.
• W2014198003 hasLocation W20141980031 @default.
• W2014198003 hasLocation W20141980032 @default.
• W2014198003 hasOpenAccess W2014198003 @default.
• W2014198003 hasPrimaryLocation W20141980031 @default.
• W2014198003 hasRelatedWork W1978760124 @default.
• W2014198003 hasRelatedWork W2004726042 @default.
• W2014198003 hasRelatedWork W2012461147 @default.
• W2014198003 hasRelatedWork W2020034592 @default.

• next