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- W2014199384 abstract "Gene-based delivery of recombinant antibody genes is a promising therapeutic strategy offering numerous advantages including sustained antibody levels, better safety profile and lower production cost. Here we describe generation of a recombinant antibody Fc-9E2 comprising a fusion protein between human Fc of IgG1 and a single-chain Fv derived from a hybridoma 9E2 secreting a mAb neutralizing West Nile virus (WNV). Fc-9E2 was shown to retain parental mAb's specificity and WNV-neutralizing capacity. Adenovirus-mediated in vivo delivery of the antibody gene resulted in sustained Fc-9E2 serum levels leading to abrogation of lethal WNV infection in an animal model." @default.
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- W2014199384 date "2008-01-01" @default.
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- W2014199384 title "Genetically delivered antibody protects against West Nile virus" @default.
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- W2014199384 doi "https://doi.org/10.1016/j.antiviral.2007.08.010" @default.
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