FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014201528> ?p ?o ?g. }

• W2014201528 endingPage "293" @default.
• W2014201528 startingPage "288" @default.
• W2014201528 abstract "Disturbances in the sphincter of Oddi (SO) function may prevent normal bile flow and thus enhance the probability of common bile duct stone (CBDS) formation. We have previously shown increased prevalence of diagnosed hypothyroidism in CBDS patients, thyroxine (T(4)) -induced inhibition of the SO contractility both in animal and in human experiments ex vivo, and reduced bile flow to duodenum in hypothyroid rats. The aim of the present study was to investigate human biliary dynamics in relation to altered thyroid gland function.Eight female patients, 1 with diagnosed untreated hypothyroidism and 7 with total thyroidectomy performed due to thyroid cancer, were studied in hypothyroid stage and again after thyroxine replacement therapy in euthyroid stage, with quantitative (99m)Tc HIDA cholescintigraphy (QC), biliary ultrasonography, and serum determinations. Each patient served as her own control in the 2 stages of the study.In QC, maximal uptake of (99m)Tc HIDA was not changed in hypothyroidism compared to euthyroidism. The first appearance of radioactivity to large bile ducts at the hepatic hilum remained unchanged in the 2 stages of the study. Hepatic clearance of (99m)Tc HIDA was decreased at 45 minutes (28% [11-38] vs 50% [33-54]; P =.028; median and range) and at 60 minutes (55% [28-80] vs 69% [61-79]; P =.028; median and range) and hilum-duodenal transit time increased by 31% compared to euthyroid stage. In US no changes were seen in gall bladder or bile ducts in the 2 stages of the study. Serum hypercholesterolemia was observed in the hypothyroid stage.We conclude that hypothyroidism may result in delayed emptying of the biliary tract, as studied with QC. In addition to the changes in bile composition and excretion rate suggested before to take place in hypothyroidism, according to the present study changes in biliary emptying also may be included in the probable causes for the increased prevalence of CBDS in hypothyroidism. This may be due to the absence of the prorelaxing effect of thyroxine on SO, which we have shown before to exist ex vivo." @default.
• W2014201528 created "2016-06-24" @default.
• W2014201528 creator A5006288518 @default.
• W2014201528 creator A5015639185 @default.
• W2014201528 creator A5030693388 @default.
• W2014201528 creator A5038989178 @default.
• W2014201528 creator A5041932799 @default.
• W2014201528 creator A5043833151 @default.
• W2014201528 creator A5045553912 @default.
• W2014201528 date "2003-03-01" @default.
• W2014201528 modified "2023-10-14" @default.
• W2014201528 title "Is bile flow reduced in patients with hypothyroidism?" @default.
• W2014201528 cites W1488284148 @default.
• W2014201528 cites W162191603 @default.
• W2014201528 cites W18962168 @default.
• W2014201528 cites W1983434334 @default.
• W2014201528 cites W1997546890 @default.
• W2014201528 cites W2004422505 @default.
• W2014201528 cites W2032045474 @default.
• W2014201528 cites W2041686296 @default.
• W2014201528 cites W2050836486 @default.
• W2014201528 cites W2075495934 @default.
• W2014201528 cites W2090060155 @default.
• W2014201528 cites W2095392249 @default.
• W2014201528 cites W2125000920 @default.
• W2014201528 cites W2171336901 @default.
• W2014201528 cites W2180150471 @default.
• W2014201528 cites W2279875305 @default.
• W2014201528 cites W2334419274 @default.
• W2014201528 cites W4244654800 @default.
• W2014201528 doi "https://doi.org/10.1067/msy.2003.77" @default.
• W2014201528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12660641" @default.
• W2014201528 hasPublicationYear "2003" @default.
• W2014201528 type Work @default.
• W2014201528 sameAs 2014201528 @default.
• W2014201528 citedByCount "43" @default.
• W2014201528 countsByYear W20142015282012 @default.
• W2014201528 countsByYear W20142015282013 @default.
• W2014201528 countsByYear W20142015282014 @default.
• W2014201528 countsByYear W20142015282015 @default.
• W2014201528 countsByYear W20142015282016 @default.
• W2014201528 countsByYear W20142015282017 @default.
• W2014201528 countsByYear W20142015282018 @default.
• W2014201528 countsByYear W20142015282019 @default.
• W2014201528 countsByYear W20142015282020 @default.
• W2014201528 countsByYear W20142015282021 @default.
• W2014201528 countsByYear W20142015282022 @default.
• W2014201528 countsByYear W20142015282023 @default.
• W2014201528 crossrefType "journal-article" @default.
• W2014201528 hasAuthorship W2014201528A5006288518 @default.
• W2014201528 hasAuthorship W2014201528A5015639185 @default.
• W2014201528 hasAuthorship W2014201528A5030693388 @default.
• W2014201528 hasAuthorship W2014201528A5038989178 @default.
• W2014201528 hasAuthorship W2014201528A5041932799 @default.
• W2014201528 hasAuthorship W2014201528A5043833151 @default.
• W2014201528 hasAuthorship W2014201528A5045553912 @default.
• W2014201528 hasConcept C126322002 @default.
• W2014201528 hasConcept C134018914 @default.
• W2014201528 hasConcept C141071460 @default.
• W2014201528 hasConcept C2776629433 @default.
• W2014201528 hasConcept C2776809568 @default.
• W2014201528 hasConcept C2776884468 @default.
• W2014201528 hasConcept C2777148285 @default.
• W2014201528 hasConcept C2777195454 @default.
• W2014201528 hasConcept C2777891700 @default.
• W2014201528 hasConcept C2779777945 @default.
• W2014201528 hasConcept C2779819216 @default.
• W2014201528 hasConcept C39133596 @default.
• W2014201528 hasConcept C526584372 @default.
• W2014201528 hasConcept C71924100 @default.
• W2014201528 hasConcept C90924648 @default.
• W2014201528 hasConceptScore W2014201528C126322002 @default.
• W2014201528 hasConceptScore W2014201528C134018914 @default.
• W2014201528 hasConceptScore W2014201528C141071460 @default.
• W2014201528 hasConceptScore W2014201528C2776629433 @default.
• W2014201528 hasConceptScore W2014201528C2776809568 @default.
• W2014201528 hasConceptScore W2014201528C2776884468 @default.
• W2014201528 hasConceptScore W2014201528C2777148285 @default.
• W2014201528 hasConceptScore W2014201528C2777195454 @default.
• W2014201528 hasConceptScore W2014201528C2777891700 @default.
• W2014201528 hasConceptScore W2014201528C2779777945 @default.
• W2014201528 hasConceptScore W2014201528C2779819216 @default.
• W2014201528 hasConceptScore W2014201528C39133596 @default.
• W2014201528 hasConceptScore W2014201528C526584372 @default.
• W2014201528 hasConceptScore W2014201528C71924100 @default.
• W2014201528 hasConceptScore W2014201528C90924648 @default.
• W2014201528 hasIssue "3" @default.
• W2014201528 hasLocation W20142015281 @default.
• W2014201528 hasLocation W20142015282 @default.
• W2014201528 hasOpenAccess W2014201528 @default.
• W2014201528 hasPrimaryLocation W20142015281 @default.
• W2014201528 hasRelatedWork W1723709744 @default.
• W2014201528 hasRelatedWork W1981790967 @default.
• W2014201528 hasRelatedWork W2011960454 @default.
• W2014201528 hasRelatedWork W2327650440 @default.
• W2014201528 hasRelatedWork W2415232792 @default.
• W2014201528 hasRelatedWork W2473308304 @default.
• W2014201528 hasRelatedWork W2748952813 @default.

• next