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- W2014201740 abstract "Comparison was made between the effects of isoproterenol and glucagon on myocardial ischemic injury following acute coronary artery occlusion in 8 dogs. Maximal rate of left ventricular pressure rise (dP/dt) was similarly increased by isoproterenol (63 ± 6 %) (mean ± S.E.M.) and glucagon (65 ± 5 %) infusions. Ischemic injury was measured as the sum of S-T segment elevations in epicardial ECG recordings from 8–10 sites (σST). σST during coronary artery occlusion alone averaged 22 ± 1 mV. Reocclusion of the artery performed during isoproterenol infusion increased σST to 70 ± 7 mV, while during glucagon σST rose to only 51 ± 7 mV. The difference in σST obtained with isoproterenol and glucagon was statistically significant (P < 0.001). Arterial concentrations of free fatty acids (FFAa) were raised from 225 ± 26 to 1213 ± 166 μEq/l by isoproterenol (P < 0.001), whereas glucagon had no significant effect upon FFAa. The experiments were repeated after inhibition of catecholamine-induced lipolysis with β-pyridyl ..." @default.
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- W2014201740 title "Effects of Glucagon and Isoproterenol on Severity of Acute Myocardial Ischemic Injury" @default.
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