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- W2014201907 abstract "A novel sample clean-up technique, water-compatible, molecularly imprinted, solid-phase extraction (MISPE), combined with high-performance liquid chromatography (HPLC), was developed and validated for selective extraction and determination of lacosamide in rat plasma. The molecularly imprinted polymer (MIP) was synthesized using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, chloroform as a porogen, and lacosamide as a template. Its efficacy as a selective sorbent in solid-phase extraction of lacosamide and the effects of various porogenic solvents, pH, crosslinker, and amount of monomer were studied and optimized. The recovery was >98% with a detection limit of 0.03 μg mL−1 over a linear range of 0.1–100 μg mL−1." @default.
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- W2014201907 date "2014-01-01" @default.
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- W2014201907 title "Molecularly imprinted polymer-based, solid-phase extraction followed by liquid chromatographic determination of lacosamide in rat plasma" @default.
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- W2014201907 doi "https://doi.org/10.1039/c3ay42186d" @default.
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