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• W2014203888 abstract "Traditionally, the mainstays of invasive bladder cancer treatment have been surgery, radiotherapy, or combinations of both. However, more than 50% of patients with deeply invasive disease ultimately relapse, and thus better therapeutic options have been sought. Important prognostic factors for patients with metastatic bladder cancer include sites of disease and histologic characteristics of the primary tumor. Treatment of metastatic disease consists primarily of systemic chemotherapy; a variety of chemotherapy regimens have been evaluated, and newer cytotoxic agents are now being evaluated in clinical trials. In an effort to improve cure rates, combined modality regimens are now being investigated. These include neoadjuvant chemotherapy (either single agent or combination regimens) followed by radiotherapy, concurrent chemoradiotherapy, and radiotherapy and/or surgery followed by adjuvant chemotherapy. Although results of early clinical trials evaluating each of these approaches generally have been promising, randomized clinical trials have mostly failed to show any survival benefit from neoadjuvant chemotherapy. Concurrent chemoradiation and regimens of adjuvant chemotherapy have not yet been adequately tested in randomized trials. Today's health care environment is slowing research in the treatment of invasive bladder cancer; academic clinicians and the oncology treatment community must unite to maintain standards and protect our ability to make continued progress." @default.
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• W2014203888 date "1997-07-01" @default.
• W2014203888 modified "2023-09-27" @default.
• W2014203888 title "Management of invasive bladder cancer: Strategies of combined modality treatment" @default.
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• W2014203888 doi "https://doi.org/10.1016/s1053-4296(97)80059-8" @default.
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