Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014205562> ?p ?o ?g. }
- W2014205562 endingPage "1822" @default.
- W2014205562 startingPage "1813" @default.
- W2014205562 abstract "In this article, we develop an evolutionary model for protein sequence evolution. Gene pleiotropy is characterized by K distinct but correlated components (molecular phenotypes) that affect the organismal fitness. These K molecular phenotypes are under stabilizing selection with microadaptation (SM) due to random optima shifts, the SM model. Random coding mutations generate a correlated distribution of K molecular phenotypes. Under this SM model, we further develop a statistical method to estimate the effective number of molecular phenotypes (K(e)) of the gene. Therefore, for the first time we can empirically evaluate gene pleiotropy from the protein sequence analysis. Case studies of vertebrate proteins indicate that K(e) is typically approximately 6-9. We demonstrate that the newly developed SM model of protein evolution may provide a basis for exploring genomic evolution and correlations." @default.
- W2014205562 created "2016-06-24" @default.
- W2014205562 creator A5080712092 @default.
- W2014205562 date "2007-04-01" @default.
- W2014205562 modified "2023-09-23" @default.
- W2014205562 title "Evolutionary Framework for Protein Sequence Evolution and Gene Pleiotropy" @default.
- W2014205562 cites W1897869592 @default.
- W2014205562 cites W1931969146 @default.
- W2014205562 cites W1983679519 @default.
- W2014205562 cites W1993900316 @default.
- W2014205562 cites W2001153871 @default.
- W2014205562 cites W2004353035 @default.
- W2014205562 cites W2005584780 @default.
- W2014205562 cites W2005869314 @default.
- W2014205562 cites W2007325254 @default.
- W2014205562 cites W2011812857 @default.
- W2014205562 cites W2046602549 @default.
- W2014205562 cites W2055346334 @default.
- W2014205562 cites W2066363086 @default.
- W2014205562 cites W2085683389 @default.
- W2014205562 cites W2094223277 @default.
- W2014205562 cites W2099505984 @default.
- W2014205562 cites W2112945902 @default.
- W2014205562 cites W2115148114 @default.
- W2014205562 cites W2117420753 @default.
- W2014205562 cites W2119632499 @default.
- W2014205562 cites W2136038427 @default.
- W2014205562 cites W2139079568 @default.
- W2014205562 cites W2142598867 @default.
- W2014205562 cites W2144206507 @default.
- W2014205562 cites W2146453000 @default.
- W2014205562 cites W2147659161 @default.
- W2014205562 cites W2149177128 @default.
- W2014205562 cites W2149915402 @default.
- W2014205562 cites W2156470286 @default.
- W2014205562 cites W2158246396 @default.
- W2014205562 cites W2161819299 @default.
- W2014205562 cites W2163963584 @default.
- W2014205562 cites W2168135370 @default.
- W2014205562 cites W2169079604 @default.
- W2014205562 cites W2169225803 @default.
- W2014205562 cites W2169947310 @default.
- W2014205562 cites W2170675417 @default.
- W2014205562 cites W2180177760 @default.
- W2014205562 cites W2286962642 @default.
- W2014205562 cites W2298672319 @default.
- W2014205562 cites W2462327257 @default.
- W2014205562 cites W4243747842 @default.
- W2014205562 doi "https://doi.org/10.1534/genetics.106.066530" @default.
- W2014205562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1855142" @default.
- W2014205562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17277368" @default.
- W2014205562 hasPublicationYear "2007" @default.
- W2014205562 type Work @default.
- W2014205562 sameAs 2014205562 @default.
- W2014205562 citedByCount "29" @default.
- W2014205562 countsByYear W20142055622012 @default.
- W2014205562 countsByYear W20142055622013 @default.
- W2014205562 countsByYear W20142055622014 @default.
- W2014205562 countsByYear W20142055622015 @default.
- W2014205562 countsByYear W20142055622022 @default.
- W2014205562 crossrefType "journal-article" @default.
- W2014205562 hasAuthorship W2014205562A5080712092 @default.
- W2014205562 hasBestOaLocation W20142055622 @default.
- W2014205562 hasConcept C104317684 @default.
- W2014205562 hasConcept C127716648 @default.
- W2014205562 hasConcept C1570309 @default.
- W2014205562 hasConcept C166393388 @default.
- W2014205562 hasConcept C26207810 @default.
- W2014205562 hasConcept C2778112365 @default.
- W2014205562 hasConcept C54355233 @default.
- W2014205562 hasConcept C70721500 @default.
- W2014205562 hasConcept C78458016 @default.
- W2014205562 hasConcept C86803240 @default.
- W2014205562 hasConcept C90132467 @default.
- W2014205562 hasConcept C91779695 @default.
- W2014205562 hasConceptScore W2014205562C104317684 @default.
- W2014205562 hasConceptScore W2014205562C127716648 @default.
- W2014205562 hasConceptScore W2014205562C1570309 @default.
- W2014205562 hasConceptScore W2014205562C166393388 @default.
- W2014205562 hasConceptScore W2014205562C26207810 @default.
- W2014205562 hasConceptScore W2014205562C2778112365 @default.
- W2014205562 hasConceptScore W2014205562C54355233 @default.
- W2014205562 hasConceptScore W2014205562C70721500 @default.
- W2014205562 hasConceptScore W2014205562C78458016 @default.
- W2014205562 hasConceptScore W2014205562C86803240 @default.
- W2014205562 hasConceptScore W2014205562C90132467 @default.
- W2014205562 hasConceptScore W2014205562C91779695 @default.
- W2014205562 hasIssue "4" @default.
- W2014205562 hasLocation W20142055621 @default.
- W2014205562 hasLocation W20142055622 @default.
- W2014205562 hasLocation W20142055623 @default.
- W2014205562 hasLocation W20142055624 @default.
- W2014205562 hasOpenAccess W2014205562 @default.
- W2014205562 hasPrimaryLocation W20142055621 @default.
- W2014205562 hasRelatedWork W1530402712 @default.
- W2014205562 hasRelatedWork W2125731289 @default.
- W2014205562 hasRelatedWork W2132060660 @default.
- W2014205562 hasRelatedWork W2132993604 @default.