FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014207795> ?p ?o ?g. }

• W2014207795 endingPage "3468" @default.
• W2014207795 startingPage "3459" @default.
• W2014207795 abstract "Soluble HLA class I (sHLA-I) molecules can regulate survival of NK cells and their anti-tumor killing activity. Herein, we have analysed whether interaction of sHLA-I with CD8 and/or different isoforms of killer Ig-like receptors (KIR) induced secretion of transforming growth factor (TGF)-beta1. CD8+KIR- NK cell clones secreted TGF-beta1 upon the interaction of sHLA-I with CD8 molecule. sHLA-Cw4 or sHLA-Cw3 alleles engaging inhibitory isoforms of KIR, namely KIR2DL1 or KIR2DL2, strongly downregulated TGF-beta1 production elicited through CD8. On the other hand, sHLA-Cw4 or sHLA-Cw3 alleles induced secretion of TGF-beta1 by ligation of stimulatory KIR2DS1 or KIR2DS2 isoforms. TGF-beta1 strongly reduced NK cell-mediated tumor cell lysis and production of pro-inflammatory cytokines such as TNF-alpha and IFN-gamma. Also, TGF-beta1 inhibited NK cell cytolysis induced by the engagement of stimulatory receptors including NKG2D, DNAM1, 2B4, CD69, NKp30, NKp44 and NKp46. The IL-2-dependent surface upregulation of some of these receptors was prevented by TGF-beta1. Furthermore, TGF-beta1 hampered IL-2-induced NK cell proliferation but not IL-2-mediated rescue from apoptosis of NK cells. Depletion of TGF-beta1 restored all the NK cell-mediated functional activities analysed. Taken together these findings suggest that sHLA-I antigens may downregulate the NK cell-mediated innate response by inducing TGF-beta1 release." @default.
• W2014207795 created "2016-06-24" @default.
• W2014207795 creator A5021752739 @default.
• W2014207795 creator A5036055913 @default.
• W2014207795 creator A5045982942 @default.
• W2014207795 creator A5049096801 @default.
• W2014207795 creator A5071597978 @default.
• W2014207795 creator A5076398704 @default.
• W2014207795 date "2009-10-14" @default.
• W2014207795 modified "2023-10-06" @default.
• W2014207795 title "Soluble HLA-I-mediated secretion of TGF-β1 by human NK cells and consequent down-regulation of anti-tumor cytolytic activity" @default.
• W2014207795 cites W1972144232 @default.
• W2014207795 cites W1972890803 @default.
• W2014207795 cites W1987046943 @default.
• W2014207795 cites W1997399564 @default.
• W2014207795 cites W2005673485 @default.
• W2014207795 cites W2007771907 @default.
• W2014207795 cites W2036862498 @default.
• W2014207795 cites W2037416158 @default.
• W2014207795 cites W2068036571 @default.
• W2014207795 cites W2077919419 @default.
• W2014207795 cites W2078985610 @default.
• W2014207795 cites W2080435876 @default.
• W2014207795 cites W2092351680 @default.
• W2014207795 cites W2095046039 @default.
• W2014207795 cites W2113313714 @default.
• W2014207795 cites W2118447882 @default.
• W2014207795 cites W2130649175 @default.
• W2014207795 cites W2158882039 @default.
• W2014207795 cites W2160520392 @default.
• W2014207795 cites W2163988566 @default.
• W2014207795 cites W2172005924 @default.
• W2014207795 cites W2172180689 @default.
• W2014207795 cites W2316067769 @default.
• W2014207795 doi "https://doi.org/10.1002/eji.200939728" @default.
• W2014207795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19830740" @default.
• W2014207795 hasPublicationYear "2009" @default.
• W2014207795 type Work @default.
• W2014207795 sameAs 2014207795 @default.
• W2014207795 citedByCount "29" @default.
• W2014207795 countsByYear W20142077952012 @default.
• W2014207795 countsByYear W20142077952013 @default.
• W2014207795 countsByYear W20142077952014 @default.
• W2014207795 countsByYear W20142077952015 @default.
• W2014207795 countsByYear W20142077952016 @default.
• W2014207795 countsByYear W20142077952017 @default.
• W2014207795 countsByYear W20142077952021 @default.
• W2014207795 crossrefType "journal-article" @default.
• W2014207795 hasAuthorship W2014207795A5021752739 @default.
• W2014207795 hasAuthorship W2014207795A5036055913 @default.
• W2014207795 hasAuthorship W2014207795A5045982942 @default.
• W2014207795 hasAuthorship W2014207795A5049096801 @default.
• W2014207795 hasAuthorship W2014207795A5071597978 @default.
• W2014207795 hasAuthorship W2014207795A5076398704 @default.
• W2014207795 hasBestOaLocation W20142077951 @default.
• W2014207795 hasConcept C118131993 @default.
• W2014207795 hasConcept C129374314 @default.
• W2014207795 hasConcept C134018914 @default.
• W2014207795 hasConcept C147483822 @default.
• W2014207795 hasConcept C153911025 @default.
• W2014207795 hasConcept C154317977 @default.
• W2014207795 hasConcept C167672396 @default.
• W2014207795 hasConcept C170493617 @default.
• W2014207795 hasConcept C183315844 @default.
• W2014207795 hasConcept C202751555 @default.
• W2014207795 hasConcept C203014093 @default.
• W2014207795 hasConcept C2776062744 @default.
• W2014207795 hasConcept C49039625 @default.
• W2014207795 hasConcept C55493867 @default.
• W2014207795 hasConcept C73588182 @default.
• W2014207795 hasConcept C86803240 @default.
• W2014207795 hasConcept C95444343 @default.
• W2014207795 hasConceptScore W2014207795C118131993 @default.
• W2014207795 hasConceptScore W2014207795C129374314 @default.
• W2014207795 hasConceptScore W2014207795C134018914 @default.
• W2014207795 hasConceptScore W2014207795C147483822 @default.
• W2014207795 hasConceptScore W2014207795C153911025 @default.
• W2014207795 hasConceptScore W2014207795C154317977 @default.
• W2014207795 hasConceptScore W2014207795C167672396 @default.
• W2014207795 hasConceptScore W2014207795C170493617 @default.
• W2014207795 hasConceptScore W2014207795C183315844 @default.
• W2014207795 hasConceptScore W2014207795C202751555 @default.
• W2014207795 hasConceptScore W2014207795C203014093 @default.
• W2014207795 hasConceptScore W2014207795C2776062744 @default.
• W2014207795 hasConceptScore W2014207795C49039625 @default.
• W2014207795 hasConceptScore W2014207795C55493867 @default.
• W2014207795 hasConceptScore W2014207795C73588182 @default.
• W2014207795 hasConceptScore W2014207795C86803240 @default.
• W2014207795 hasConceptScore W2014207795C95444343 @default.
• W2014207795 hasIssue "12" @default.
• W2014207795 hasLocation W20142077951 @default.
• W2014207795 hasLocation W20142077952 @default.
• W2014207795 hasOpenAccess W2014207795 @default.
• W2014207795 hasPrimaryLocation W20142077951 @default.
• W2014207795 hasRelatedWork W1943593754 @default.
• W2014207795 hasRelatedWork W1969504080 @default.
• W2014207795 hasRelatedWork W1980376067 @default.
• W2014207795 hasRelatedWork W2049687639 @default.

• next