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• W2014207892 abstract "Thyroid hormone receptor (TR), as a member of the nuclear hormone receptor family, can recognize and bind different classes of DNA response element targets as either a monomer, a homooligomer, or a heterooligomer. We report here the first crystal structure of a homodimer TR DNA-binding domain (DBD) in complex with an inverted repeat class of thyroid response element (TRE). The structure shows a nearly symmetric structure of the TR DBD assembled on the F2 TRE where the base recognition contacts in the homodimer DNA complex are conserved relative to the previously published structure of a TR-9-cis-retinoic acid receptor heterodimer DNA complex. The new structure also reveals that the T-box region of the DBD can function as a structural hinge that enables a large degree of flexibility in the position of the C-terminal extension helix that connects the DBD to the ligand-binding domain. Although the isolated TR DBDs exist as monomers in solution, we have measured highly cooperative binding of the two TR DBD subunits onto the inverted repeat DNA sequence. This suggests that elements of the DBD can influence the specific TR oligomerization at target genes, and it is not just interactions between the ligand-binding domains that are responsible for TR oligomerization at target genes. Mutational analysis shows that intersubunit contacts at the DBD C terminus account for some, but not all, of the cooperative homodimer TR binding to the inverted repeat class TRE." @default.
• W2014207892 created "2016-06-24" @default.
• W2014207892 creator A5071610055 @default.
• W2014207892 creator A5088323648 @default.
• W2014207892 date "2010-08-01" @default.
• W2014207892 modified "2023-10-16" @default.
• W2014207892 title "Structure of a Thyroid Hormone Receptor DNA-Binding Domain Homodimer Bound to an Inverted Palindrome DNA Response Element" @default.
• W2014207892 cites W110453064 @default.
• W2014207892 cites W1486845435 @default.
• W2014207892 cites W1487719143 @default.
• W2014207892 cites W1539796472 @default.
• W2014207892 cites W1541313045 @default.
• W2014207892 cites W1551079448 @default.
• W2014207892 cites W1583654353 @default.
• W2014207892 cites W1607714362 @default.
• W2014207892 cites W1855128821 @default.
• W2014207892 cites W1881800315 @default.
• W2014207892 cites W1963643987 @default.
• W2014207892 cites W1975191711 @default.
• W2014207892 cites W1976263202 @default.
• W2014207892 cites W1978129691 @default.
• W2014207892 cites W1983541481 @default.
• W2014207892 cites W1985247182 @default.
• W2014207892 cites W1985865142 @default.
• W2014207892 cites W1987783037 @default.
• W2014207892 cites W1990529844 @default.
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• W2014207892 cites W1995754186 @default.
• W2014207892 cites W2005385197 @default.
• W2014207892 cites W2006622169 @default.
• W2014207892 cites W2011467252 @default.
• W2014207892 cites W2012017889 @default.
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• W2014207892 cites W2026298200 @default.
• W2014207892 cites W2034607609 @default.
• W2014207892 cites W2035346614 @default.
• W2014207892 cites W2040053707 @default.
• W2014207892 cites W2042901562 @default.
• W2014207892 cites W2046048837 @default.
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• W2014207892 cites W2065209749 @default.
• W2014207892 cites W2065485581 @default.
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• W2014207892 cites W2076524169 @default.
• W2014207892 cites W2076636226 @default.
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• W2014207892 doi "https://doi.org/10.1210/me.2010-0129" @default.
• W2014207892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5417456" @default.
• W2014207892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20610536" @default.
• W2014207892 hasPublicationYear "2010" @default.
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