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• W2014219207 abstract "T cell growth and function must be tightly regulated to provide protection against foreign pathogens, while avoiding autoimmunity and immunodeficiency. It is now apparent that T cell metabolism is highly dynamic and has a tremendous impact on the ability of T cells to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors that must support specific cell functions, as effector, regulatory, memory, and alloreactive T cells have distinct metabolic needs in immunity and inflammation. Here, we review the signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with T cell function. Ultimately, these metabolic differences may provide new opportunities to modulate the immune response and treat inflammatory and autoimmune diseases. T cell growth and function must be tightly regulated to provide protection against foreign pathogens, while avoiding autoimmunity and immunodeficiency. It is now apparent that T cell metabolism is highly dynamic and has a tremendous impact on the ability of T cells to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors that must support specific cell functions, as effector, regulatory, memory, and alloreactive T cells have distinct metabolic needs in immunity and inflammation. Here, we review the signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with T cell function. Ultimately, these metabolic differences may provide new opportunities to modulate the immune response and treat inflammatory and autoimmune diseases." @default.
• W2014219207 created "2016-06-24" @default.
• W2014219207 creator A5032790231 @default.
• W2014219207 creator A5056373193 @default.
• W2014219207 date "2012-04-01" @default.
• W2014219207 modified "2023-10-12" @default.
• W2014219207 title "Metabolic pathways in T cell fate and function" @default.
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• W2014219207 doi "https://doi.org/10.1016/j.it.2012.01.010" @default.
• W2014219207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3319512" @default.
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