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- W2014221195 abstract "LacI- mutants obtained following 2 and 6 h of thymine deprivation were cloned and sequenced. The mutational spectra recovered were dissimilar. After 2 h of starvation the majority of mutations were base substitutions, largely G:C----C:G transversions. Frameshift mutations but not deletions were observed. In contrast, following 6 h of starvation, with the exception of the G:C----C:G transversion, all possible base substitutions were recovered. Moreover, several deletions but no frameshift events were observed. The differences in the mutational spectra recovered after the two periods of thymine deprivation highlight the role of altered nucleotide pools and the potential influence of DNA replication and repair mechanisms." @default.
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- W2014221195 date "1988-07-01" @default.
- W2014221195 modified "2023-10-17" @default.
- W2014221195 title "Mutational specificity of thymine deprivation-induced mutation in the lacI gene of Escherichia coli" @default.
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- W2014221195 doi "https://doi.org/10.1016/0027-5107(88)90080-2" @default.
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