FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014231736> ?p ?o ?g. }

• W2014231736 endingPage "325" @default.
• W2014231736 startingPage "318" @default.
• W2014231736 abstract "BACKGROUND Bcl-2 protein is believed to play a role in neoplasia by inhibiting tumor cell apoptosis. To assess its contribution to gallbladder tumorigenesis and cancer progression, an immunohistochemical study was performed. METHODS Fifteen adenomas and 68 adenocarcinomas were immunohistochemically and histopathologically investigated for the relation of Bcl-2 expression to p53 status, apoptosis (apoptotic index, AI), and proliferation activity (mitotic index, MI; Ki-67 labeling index, Ki-67 LI). RESULTS The Bcl-2 score, based on intensity and extent, decreased in the order of adenoma, well-differentiated, and moderately to poorly differentiated adenocarcinoma. Early stage carcinomas demonstrated significantly higher Bcl-2 scores than their advanced counterparts (P < 0.05). On the other hand, p53 score, MI, Ki-67 LI, and AI increased in the same order. The Bcl-2 negative adenocarcinomas displayed higher AI and AI-to-MI ratios than the Bcl-2 positive group, especially in the early stage, well-differentiated lesions. A significantly positive correlation between MI(r = 0.549) or Ki-67 LI(r = 0.446) and AI was observed. In early stage carcinomas, adenomatous components in the lesions were found more frequently in the polypoid lesions than in the nonpolypoid lesions (P < 0.05). CONCLUSIONS Expression of Bcl-2 protein in gallbladder tumors appears to be positively associated with tumor cell differentiation and inversely with tumor progression. It may thus play a role in regulating carcinoma growth, especially in the early stage of tumorigenesis. It is believed that the polypoid carcinomas may arise from preexisting adenomas but the nonpolypoid carcinomas may arise as de novo carcinoma. Cancer 1999;85:318–25. © 1999 American Cancer Society." @default.
• W2014231736 created "2016-06-24" @default.
• W2014231736 creator A5002456826 @default.
• W2014231736 creator A5028736324 @default.
• W2014231736 creator A5046708618 @default.
• W2014231736 creator A5058983573 @default.
• W2014231736 creator A5061655465 @default.
• W2014231736 date "1999-01-15" @default.
• W2014231736 modified "2023-09-26" @default.
• W2014231736 title "Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis" @default.
• W2014231736 cites W1963570030 @default.
• W2014231736 cites W1965202064 @default.
• W2014231736 cites W1970019219 @default.
• W2014231736 cites W1976570855 @default.
• W2014231736 cites W1983428933 @default.
• W2014231736 cites W1986076862 @default.
• W2014231736 cites W1992904894 @default.
• W2014231736 cites W2020752442 @default.
• W2014231736 cites W2027956847 @default.
• W2014231736 cites W2032529368 @default.
• W2014231736 cites W2041185040 @default.
• W2014231736 cites W2050679471 @default.
• W2014231736 cites W2051108434 @default.
• W2014231736 cites W2057166634 @default.
• W2014231736 cites W2058592470 @default.
• W2014231736 cites W2081259481 @default.
• W2014231736 cites W2088098884 @default.
• W2014231736 cites W2094057814 @default.
• W2014231736 cites W2095561203 @default.
• W2014231736 cites W2123937294 @default.
• W2014231736 cites W2168009353 @default.
• W2014231736 cites W2334088716 @default.
• W2014231736 cites W4254118425 @default.
• W2014231736 doi "https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<318::aid-cncr8>3.0.co;2-s" @default.
• W2014231736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10023698" @default.
• W2014231736 hasPublicationYear "1999" @default.
• W2014231736 type Work @default.
• W2014231736 sameAs 2014231736 @default.
• W2014231736 citedByCount "45" @default.
• W2014231736 countsByYear W20142317362012 @default.
• W2014231736 countsByYear W20142317362013 @default.
• W2014231736 countsByYear W20142317362014 @default.
• W2014231736 countsByYear W20142317362015 @default.
• W2014231736 countsByYear W20142317362016 @default.
• W2014231736 countsByYear W20142317362017 @default.
• W2014231736 countsByYear W20142317362018 @default.
• W2014231736 countsByYear W20142317362020 @default.
• W2014231736 countsByYear W20142317362021 @default.
• W2014231736 countsByYear W20142317362022 @default.
• W2014231736 crossrefType "journal-article" @default.
• W2014231736 hasAuthorship W2014231736A5002456826 @default.
• W2014231736 hasAuthorship W2014231736A5028736324 @default.
• W2014231736 hasAuthorship W2014231736A5046708618 @default.
• W2014231736 hasAuthorship W2014231736A5058983573 @default.
• W2014231736 hasAuthorship W2014231736A5061655465 @default.
• W2014231736 hasBestOaLocation W20142317361 @default.
• W2014231736 hasConcept C121608353 @default.
• W2014231736 hasConcept C126322002 @default.
• W2014231736 hasConcept C142724271 @default.
• W2014231736 hasConcept C146357865 @default.
• W2014231736 hasConcept C151730666 @default.
• W2014231736 hasConcept C190283241 @default.
• W2014231736 hasConcept C204232928 @default.
• W2014231736 hasConcept C2776534502 @default.
• W2014231736 hasConcept C2777148285 @default.
• W2014231736 hasConcept C2777428134 @default.
• W2014231736 hasConcept C2777546739 @default.
• W2014231736 hasConcept C2777751288 @default.
• W2014231736 hasConcept C2779256057 @default.
• W2014231736 hasConcept C2781182431 @default.
• W2014231736 hasConcept C2910938049 @default.
• W2014231736 hasConcept C502942594 @default.
• W2014231736 hasConcept C55493867 @default.
• W2014231736 hasConcept C555283112 @default.
• W2014231736 hasConcept C66640590 @default.
• W2014231736 hasConcept C71924100 @default.
• W2014231736 hasConcept C86803240 @default.
• W2014231736 hasConcept C93304396 @default.
• W2014231736 hasConcept C95444343 @default.
• W2014231736 hasConceptScore W2014231736C121608353 @default.
• W2014231736 hasConceptScore W2014231736C126322002 @default.
• W2014231736 hasConceptScore W2014231736C142724271 @default.
• W2014231736 hasConceptScore W2014231736C146357865 @default.
• W2014231736 hasConceptScore W2014231736C151730666 @default.
• W2014231736 hasConceptScore W2014231736C190283241 @default.
• W2014231736 hasConceptScore W2014231736C204232928 @default.
• W2014231736 hasConceptScore W2014231736C2776534502 @default.
• W2014231736 hasConceptScore W2014231736C2777148285 @default.
• W2014231736 hasConceptScore W2014231736C2777428134 @default.
• W2014231736 hasConceptScore W2014231736C2777546739 @default.
• W2014231736 hasConceptScore W2014231736C2777751288 @default.
• W2014231736 hasConceptScore W2014231736C2779256057 @default.
• W2014231736 hasConceptScore W2014231736C2781182431 @default.
• W2014231736 hasConceptScore W2014231736C2910938049 @default.
• W2014231736 hasConceptScore W2014231736C502942594 @default.
• W2014231736 hasConceptScore W2014231736C55493867 @default.
• W2014231736 hasConceptScore W2014231736C555283112 @default.
• W2014231736 hasConceptScore W2014231736C66640590 @default.

• next