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- W2014232561 abstract "Large mammals, including canids and felids, are affected by spontaneously occurring hereditary retinal diseases with similarities to those of humans. The large mammal models may be used for thorough clinical characterization of disease processes, understanding the effects of specific mutations, elucidation of disease mechanisms, and for development of therapeutic intervention. Two well-characterized feline models are addressed in this paper. The first model is the autosomal recessive, slowly progressive, late-onset, rod-cone degenerative disease caused by a mutation in the CEP290 gene. The second model addressed in this paper is the autosomal dominant early onset rod cone dysplasia, putatively caused by the mutation found in the CRX gene. Therapeutic trials have been performed mainly in the former type including stem cell therapy, retinal transplantation, and development of ocular prosthetics. Domestic cats, having large human-like eyes with comparable spontaneous retinal diseases, are also considered useful for gene replacement therapy, thus functioning as effective model systems for further research." @default.
- W2014232561 created "2016-06-24" @default.
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- W2014232561 date "2011-01-01" @default.
- W2014232561 modified "2023-10-13" @default.
- W2014232561 title "The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness" @default.
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- W2014232561 cites W1969537396 @default.
- W2014232561 cites W1975995116 @default.
- W2014232561 cites W1980228755 @default.
- W2014232561 cites W1981244256 @default.
- W2014232561 cites W1982162156 @default.
- W2014232561 cites W1988589573 @default.
- W2014232561 cites W1989790836 @default.
- W2014232561 cites W1990953866 @default.
- W2014232561 cites W1994730862 @default.
- W2014232561 cites W1996064503 @default.
- W2014232561 cites W1998822842 @default.
- W2014232561 cites W2003494557 @default.
- W2014232561 cites W2003575173 @default.
- W2014232561 cites W2003994112 @default.
- W2014232561 cites W2004380554 @default.
- W2014232561 cites W2006529921 @default.
- W2014232561 cites W2008158370 @default.
- W2014232561 cites W2009127599 @default.
- W2014232561 cites W2014890026 @default.
- W2014232561 cites W2019739181 @default.
- W2014232561 cites W2022790853 @default.
- W2014232561 cites W2027066480 @default.
- W2014232561 cites W2030679912 @default.
- W2014232561 cites W2031851199 @default.
- W2014232561 cites W2033646700 @default.
- W2014232561 cites W2049890303 @default.
- W2014232561 cites W2053071424 @default.
- W2014232561 cites W2056387143 @default.
- W2014232561 cites W2056627564 @default.
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- W2014232561 doi "https://doi.org/10.1155/2011/906943" @default.
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