FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014233070> ?p ?o ?g. }

• W2014233070 endingPage "214" @default.
• W2014233070 startingPage "205" @default.
• W2014233070 abstract "We studied the effects of interleukins (IL) on in vitro IgM and IgG anti-DNA antibody production by splenic B cells from autoimmune disease-prone NZBxNZW (NZB/W) F1 mice. It was found that different interleukins regulate phenotypically distinct B cells producing separate isotype of anti-DNA antibodies. IL-2 slightly but significantly inhibited the production of IgM anti-DNA antibodies. IL-4 and IL-6 significantly enhanced the antibody production, but the effects were not so marked and inconsistent, particularly with respect to IL-6. By contrast, the effects of IL-5 were remarkable, particularly on splenic B cells from young mice. As for IgG anti-DNA antibodies, IL-6, but not other interleukins, markedly up-regulated the antibody production by splenic B cells from mice over 6 months of age, in a dose dependent fashion. Thus, the ability of B cells to produce IgG anti-DNA antibodies appears to be dependent on the surface expression of IL-6 receptor (IL-6R) at the ages when the mice begin to develop the disease. Studies of the surface phenotypes showed that while the IL-5-sensitive major IgM anti-DNA producers were CD5+Lp-3(CD43)-sIgM+, the IL-6-sensitive major IgG anti-DNA producers were CD5-Lp-3+sIgM-. However, significant amounts of IgG antibodies were also produced, in the presence of IL-6, by CD5+Lp-3+sIgM+, but not by CD5-Lp-3+sIgM+ B cells from 6-month-old mice. We suggest that surface phenotypes of anti-DNA antibody producers change from CD5+Lp-3-sIgM+IL-5R+, CD5+Lp-3+sIgM+IL-6R+ and subsequently to CD5-Lp-3+sIgM-(sIgG+)IL-6R+ in NZB/W F1 mice with aging." @default.
• W2014233070 created "2016-06-24" @default.
• W2014233070 creator A5015560849 @default.
• W2014233070 creator A5054986463 @default.
• W2014233070 creator A5064919780 @default.
• W2014233070 creator A5068354501 @default.
• W2014233070 creator A5075235588 @default.
• W2014233070 date "1993-01-01" @default.
• W2014233070 modified "2023-09-23" @default.
• W2014233070 title "Differential Sensitivity to Interleukins of CDS and CDS Anti-Dna Antibody-Producing B Cells in Murine Lupus" @default.
• W2014233070 cites W113842083 @default.
• W2014233070 cites W152429101 @default.
• W2014233070 cites W1624485603 @default.
• W2014233070 cites W1966844155 @default.
• W2014233070 cites W1973942993 @default.
• W2014233070 cites W1981863728 @default.
• W2014233070 cites W1983432571 @default.
• W2014233070 cites W1992242673 @default.
• W2014233070 cites W1995030846 @default.
• W2014233070 cites W2004054985 @default.
• W2014233070 cites W2008649002 @default.
• W2014233070 cites W2011378687 @default.
• W2014233070 cites W2012428595 @default.
• W2014233070 cites W2015430474 @default.
• W2014233070 cites W2016190951 @default.
• W2014233070 cites W2019318420 @default.
• W2014233070 cites W2023345509 @default.
• W2014233070 cites W2024145436 @default.
• W2014233070 cites W2028764720 @default.
• W2014233070 cites W2030764771 @default.
• W2014233070 cites W2044309960 @default.
• W2014233070 cites W2052525344 @default.
• W2014233070 cites W2061934270 @default.
• W2014233070 cites W2070437307 @default.
• W2014233070 cites W2070814047 @default.
• W2014233070 cites W2072492464 @default.
• W2014233070 cites W2075202068 @default.
• W2014233070 cites W2078547612 @default.
• W2014233070 cites W2102134390 @default.
• W2014233070 cites W2109402652 @default.
• W2014233070 cites W2128587758 @default.
• W2014233070 cites W2135880696 @default.
• W2014233070 cites W2143399845 @default.
• W2014233070 cites W2155027604 @default.
• W2014233070 cites W2159130461 @default.
• W2014233070 cites W2173075155 @default.
• W2014233070 cites W2177385981 @default.
• W2014233070 cites W2227157639 @default.
• W2014233070 doi "https://doi.org/10.3109/08916939309077367" @default.
• W2014233070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7687154" @default.
• W2014233070 hasPublicationYear "1993" @default.
• W2014233070 type Work @default.
• W2014233070 sameAs 2014233070 @default.
• W2014233070 citedByCount "20" @default.
• W2014233070 countsByYear W20142330702013 @default.
• W2014233070 countsByYear W20142330702014 @default.
• W2014233070 crossrefType "journal-article" @default.
• W2014233070 hasAuthorship W2014233070A5015560849 @default.
• W2014233070 hasAuthorship W2014233070A5054986463 @default.
• W2014233070 hasAuthorship W2014233070A5064919780 @default.
• W2014233070 hasAuthorship W2014233070A5068354501 @default.
• W2014233070 hasAuthorship W2014233070A5075235588 @default.
• W2014233070 hasConcept C113067387 @default.
• W2014233070 hasConcept C126322002 @default.
• W2014233070 hasConcept C137756551 @default.
• W2014233070 hasConcept C153911025 @default.
• W2014233070 hasConcept C159654299 @default.
• W2014233070 hasConcept C187316574 @default.
• W2014233070 hasConcept C191732599 @default.
• W2014233070 hasConcept C203014093 @default.
• W2014233070 hasConcept C2776912625 @default.
• W2014233070 hasConcept C2777991845 @default.
• W2014233070 hasConcept C2778453870 @default.
• W2014233070 hasConcept C2778690821 @default.
• W2014233070 hasConcept C2779134260 @default.
• W2014233070 hasConcept C542903549 @default.
• W2014233070 hasConcept C71924100 @default.
• W2014233070 hasConcept C86803240 @default.
• W2014233070 hasConceptScore W2014233070C113067387 @default.
• W2014233070 hasConceptScore W2014233070C126322002 @default.
• W2014233070 hasConceptScore W2014233070C137756551 @default.
• W2014233070 hasConceptScore W2014233070C153911025 @default.
• W2014233070 hasConceptScore W2014233070C159654299 @default.
• W2014233070 hasConceptScore W2014233070C187316574 @default.
• W2014233070 hasConceptScore W2014233070C191732599 @default.
• W2014233070 hasConceptScore W2014233070C203014093 @default.
• W2014233070 hasConceptScore W2014233070C2776912625 @default.
• W2014233070 hasConceptScore W2014233070C2777991845 @default.
• W2014233070 hasConceptScore W2014233070C2778453870 @default.
• W2014233070 hasConceptScore W2014233070C2778690821 @default.
• W2014233070 hasConceptScore W2014233070C2779134260 @default.
• W2014233070 hasConceptScore W2014233070C542903549 @default.
• W2014233070 hasConceptScore W2014233070C71924100 @default.
• W2014233070 hasConceptScore W2014233070C86803240 @default.
• W2014233070 hasIssue "3" @default.
• W2014233070 hasLocation W20142330701 @default.
• W2014233070 hasLocation W20142330702 @default.
• W2014233070 hasOpenAccess W2014233070 @default.

• next