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- W2014236026 endingPage "2356" @default.
- W2014236026 startingPage "2346" @default.
- W2014236026 abstract "The psychotomimetic drug -amphetamine (AMPH), disrupts prepulse inhibition (PPI) of the startle response, an operational measure of sensorimotor gating that is deficient in schizophrenia patients. Historically, this effect has been attributed to dopaminergic substrates; however, AMPH also increases norepinephrine (NE) levels, and enhancement of central NE transmission has been shown recently to disrupt PPI. This study examined the extent to which NE might participate in AMPH-induced disruptions of PPI and increases in locomotor activity, another classic behavioral effect of AMPH, by determining whether antagonism of postsynaptic NE receptors blocked these effects. Separate groups of male Sprague–Dawley rats received either the α1 receptor antagonist, prazosin (0, 0.3, 1 mg/kg), or the β receptor antagonist timolol (0, 3, 10 mg/kg) before administration of AMPH (0 or 1 mg/kg) before testing for PPI or locomotor activity. As an initial exploration of the anatomical substrates underlying possible α1 receptor-mediated effects on AMPH-induced PPI deficits, the α1 receptor antagonist terazosin (0 or 40 μg/0.5 μl) was microinfused into the nucleus accumbens shell (NAccSh) in conjunction with systemic AMPH administration before startle testing in a separate experiment. Prazosin, but not timolol, blocked AMPH-induced hyperactivity; both drugs reversed AMPH-induced PPI deficits without altering baseline startle responses. Interestingly, AMPH-induced PPI deficits also were partially blocked by terazosin in NAccSh. Thus, behavioral sequelae of AMPH (PPI disruption and hyperactivity) may be mediated in part by NE receptors, with α1 receptors in NAccSh possibly having an important role in the sensorimotor gating deficits induced by this psychotomimetic drug." @default.
- W2014236026 created "2016-06-24" @default.
- W2014236026 creator A5030995663 @default.
- W2014236026 creator A5049024031 @default.
- W2014236026 creator A5057859743 @default.
- W2014236026 date "2010-08-04" @default.
- W2014236026 modified "2023-10-15" @default.
- W2014236026 title "Ventral Striatal Noradrenergic Mechanisms Contribute to Sensorimotor Gating Deficits Induced by Amphetamine" @default.
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- W2014236026 doi "https://doi.org/10.1038/npp.2010.106" @default.
- W2014236026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2955791" @default.
- W2014236026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20686455" @default.
- W2014236026 hasPublicationYear "2010" @default.