FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014238399> ?p ?o ?g. }

• W2014238399 endingPage "335" @default.
• W2014238399 startingPage "329" @default.
• W2014238399 abstract "Inflammatory breast carcinoma (IBC) is a rare but aggressive tumour associated with poor outcome owing to early metastases. Increased expression of c-Met protein correlates with reduced survival and high metastatic risk in human cancers including breast carcinomas and is targetable by specific drugs, that could potentially improve the prognosis. In the present study, we compared c-Met expression in IBC (n=41) and non-IBC (n=480) immunohistochemically (Ventana Benchmark autostainer) in two tissue microarrays (TMA) along with PI3K and E-cadherin. The results were quantified through an automated image analysis device (SAMBA Technologies). We observed that (i) c-Met was significantly overexpressed in IBC as compared with non-IBC (P<0.001), (ii) PI3K was overexpressed (P<0.001) in IBC, suggesting that the overexpressed c-Met is functionally active at least through the PI3K signal transduction pathway; and (iii) E-cadherin was paradoxically also overexpressed in IBC. We concluded that overexpressed c-Met in IBC constitutes a potential target for specific therapy for the management of patients with poor-outcome tumours such as IBC. Automated image analysis of TMA proved to be a valuable tool for high-throughput immunohistochemical quantification of the expression of intratumorous protein markers." @default.
• W2014238399 created "2016-06-24" @default.
• W2014238399 creator A5012852924 @default.
• W2014238399 creator A5014608751 @default.
• W2014238399 creator A5018937682 @default.
• W2014238399 creator A5033716671 @default.
• W2014238399 creator A5034445018 @default.
• W2014238399 creator A5048568279 @default.
• W2014238399 creator A5054710012 @default.
• W2014238399 creator A5055844946 @default.
• W2014238399 creator A5056506648 @default.
• W2014238399 creator A5073328006 @default.
• W2014238399 creator A5088324209 @default.
• W2014238399 date "2007-01-01" @default.
• W2014238399 modified "2023-10-07" @default.
• W2014238399 title "c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays" @default.
• W2014238399 cites W1426393029 @default.
• W2014238399 cites W1788511812 @default.
• W2014238399 cites W1935743463 @default.
• W2014238399 cites W1985562847 @default.
• W2014238399 cites W1989259799 @default.
• W2014238399 cites W1989401198 @default.
• W2014238399 cites W1989790390 @default.
• W2014238399 cites W1992177331 @default.
• W2014238399 cites W1997306755 @default.
• W2014238399 cites W1998230962 @default.
• W2014238399 cites W2013878853 @default.
• W2014238399 cites W2018787215 @default.
• W2014238399 cites W2033974104 @default.
• W2014238399 cites W2041254904 @default.
• W2014238399 cites W2047209584 @default.
• W2014238399 cites W2054633892 @default.
• W2014238399 cites W2059860479 @default.
• W2014238399 cites W2069216067 @default.
• W2014238399 cites W2074242691 @default.
• W2014238399 cites W2083325925 @default.
• W2014238399 cites W2088989954 @default.
• W2014238399 cites W2093422551 @default.
• W2014238399 cites W2096151993 @default.
• W2014238399 cites W2096694106 @default.
• W2014238399 cites W2096844786 @default.
• W2014238399 cites W2134755472 @default.
• W2014238399 cites W2136390065 @default.
• W2014238399 cites W2137390717 @default.
• W2014238399 cites W2168203442 @default.
• W2014238399 cites W2189233644 @default.
• W2014238399 cites W2224158835 @default.
• W2014238399 cites W2232616986 @default.
• W2014238399 cites W2314139410 @default.
• W2014238399 cites W2330419910 @default.
• W2014238399 doi "https://doi.org/10.1038/sj.bjc.6603569" @default.
• W2014238399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2359990" @default.
• W2014238399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17242702" @default.
• W2014238399 hasPublicationYear "2007" @default.
• W2014238399 type Work @default.
• W2014238399 sameAs 2014238399 @default.
• W2014238399 citedByCount "36" @default.
• W2014238399 countsByYear W20142383992012 @default.
• W2014238399 countsByYear W20142383992013 @default.
• W2014238399 countsByYear W20142383992014 @default.
• W2014238399 countsByYear W20142383992015 @default.
• W2014238399 countsByYear W20142383992016 @default.
• W2014238399 countsByYear W20142383992018 @default.
• W2014238399 countsByYear W20142383992020 @default.
• W2014238399 countsByYear W20142383992021 @default.
• W2014238399 countsByYear W20142383992022 @default.
• W2014238399 countsByYear W20142383992023 @default.
• W2014238399 crossrefType "journal-article" @default.
• W2014238399 hasAuthorship W2014238399A5012852924 @default.
• W2014238399 hasAuthorship W2014238399A5014608751 @default.
• W2014238399 hasAuthorship W2014238399A5018937682 @default.
• W2014238399 hasAuthorship W2014238399A5033716671 @default.
• W2014238399 hasAuthorship W2014238399A5034445018 @default.
• W2014238399 hasAuthorship W2014238399A5048568279 @default.
• W2014238399 hasAuthorship W2014238399A5054710012 @default.
• W2014238399 hasAuthorship W2014238399A5055844946 @default.
• W2014238399 hasAuthorship W2014238399A5056506648 @default.
• W2014238399 hasAuthorship W2014238399A5073328006 @default.
• W2014238399 hasAuthorship W2014238399A5088324209 @default.
• W2014238399 hasBestOaLocation W20142383991 @default.
• W2014238399 hasConcept C121608353 @default.
• W2014238399 hasConcept C126322002 @default.
• W2014238399 hasConcept C142724271 @default.
• W2014238399 hasConcept C143998085 @default.
• W2014238399 hasConcept C193270364 @default.
• W2014238399 hasConcept C204232928 @default.
• W2014238399 hasConcept C2780839634 @default.
• W2014238399 hasConcept C3018521938 @default.
• W2014238399 hasConcept C502942594 @default.
• W2014238399 hasConcept C530470458 @default.
• W2014238399 hasConcept C71924100 @default.
• W2014238399 hasConceptScore W2014238399C121608353 @default.
• W2014238399 hasConceptScore W2014238399C126322002 @default.
• W2014238399 hasConceptScore W2014238399C142724271 @default.
• W2014238399 hasConceptScore W2014238399C143998085 @default.
• W2014238399 hasConceptScore W2014238399C193270364 @default.
• W2014238399 hasConceptScore W2014238399C204232928 @default.
• W2014238399 hasConceptScore W2014238399C2780839634 @default.

• next