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• W2014239066 abstract "Abstract Using heart-type fatty acid-binding protein (H-FABP) as an early cardiac marker for diagnosis of acute myocardial infarction (AMI) soon after the onset of symptoms requires a rapid assay. A one-step test called, CardioDetect®, is used for detection of H-FABP in whole blood sample. Thirty patients suspected of AMI presenting to the emergency department within 12 hours after onset were enrolled in this study. The diagnostic performance of CardioDetect® was compared with different cardiac markers. There were 59.1% of patients with positive H-FABP within 6 hours after onset, while there were only 18.2% with positive cardiac troponin I (cTnI). Results indicated the diagnostic power of H-FABP for AMI was significantly higher than that of cTnI. The sensitivity of H-FABP was 81.8%, which was higher than those of the other cardiac markers, while the specificity was comparable. The area under the receiver operating characteristic curve for H-FABP was 0.909, which was significantly larger than the others. With this rapid and sensitive immunotest, H-FABP could be soon introduced in clinical practice in combination with well-established markers like troponins. Keywords: acute coronary syndromesacute myocardial infarctioncreatine kinase MBheart-type fatty acid-binding proteinmyoglobintroponin ACKNOWLEDGMENTS We thank the staff of the Vasculocardiology Department of Tongde Hospital of Zhejiang Province for their dedication and for diligently ensuring the highest possible level of data capture. Notes STEMI: ST-elevation myocardial infarction; NSTEMI: non-ST-evaluation myocardial infarction; NCD: non-cardiac disease with chest pain; M: male; F: female. a Compared to control group with P < 0.0001. b Compared to STEMI group with P < 0.0001. c Compared with NSTEMI group with P < 0.05. H-FABP: heart-type fatty acid-binding protein; cTnI: cardiac troponin I; CK-MB: creatine kinase MB; MYO: myoglobin." @default.
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• W2014239066 date "2009-12-30" @default.
• W2014239066 modified "2023-10-03" @default.
• W2014239066 title "A ONE-STEP IMMUNOTEST FOR RAPID DETECTION OF HEART-TYPE FATTY ACID-BINDING PROTEIN IN PATIENTS WITH ACUTE CORONARY SYNDROMES" @default.
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• W2014239066 doi "https://doi.org/10.1080/15321810903404954" @default.
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