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• W2014239498 abstract "ObjectiveTo investigate whether secretion of soluble human leukocyte antigen-G (HLA-G) by human embryos is associated with embryo development and IVF pregnancy outcome.DesignRetrospective study.SettingIn vitro fertilization program affiliated with a university research center.Patient(s)Infertile couples attending an IVF program were selected.Intervention(s)Embryo culture conditioned medium (72 hours) from cases in which intracytoplasmic sperm injection was used for fertilization.Main outcome measure(s)Soluble HLA-G in embryo culture medium samples from IVF patients was assayed and associations between soluble HLA-G secretion and outcome measures were analyzed.Result(s)Two hundred seventy of 386 samples had detectable soluble HLA-G. Soluble HLA-G secretion was independent of embryo grade or patients' age. The cleavage rate of embryos secreting soluble HLA-G was significantly higher than that of those lacking it (blastomere number 6.71 ± 0.09 vs. 5.86 ± 0.22). The live birth rate from embryos with soluble HLA-G was significantly higher than that of those without (48.4% vs. 17.1%, χ2 = 9.09). Combining soluble HLA-G detection and cleavage rate was most predictive of pregnancy.Conclusion(s)Our five conclusions are as follows: [1] embryonic secretion of soluble HLA-G protein is variable, [2] secretion of HLA-G is correlated with a higher cleavage rate, [3] secretion of HLA-G is associated with a higher pregnancy rate, [4] HLA-G secretion is a better independent predictor than cleavage rate alone, and [5] the combination of soluble HLA-G detection and high cleavage rate was the best predictor of outcome. To investigate whether secretion of soluble human leukocyte antigen-G (HLA-G) by human embryos is associated with embryo development and IVF pregnancy outcome. Retrospective study. In vitro fertilization program affiliated with a university research center. Infertile couples attending an IVF program were selected. Embryo culture conditioned medium (72 hours) from cases in which intracytoplasmic sperm injection was used for fertilization. Soluble HLA-G in embryo culture medium samples from IVF patients was assayed and associations between soluble HLA-G secretion and outcome measures were analyzed. Two hundred seventy of 386 samples had detectable soluble HLA-G. Soluble HLA-G secretion was independent of embryo grade or patients' age. The cleavage rate of embryos secreting soluble HLA-G was significantly higher than that of those lacking it (blastomere number 6.71 ± 0.09 vs. 5.86 ± 0.22). The live birth rate from embryos with soluble HLA-G was significantly higher than that of those without (48.4% vs. 17.1%, χ2 = 9.09). Combining soluble HLA-G detection and cleavage rate was most predictive of pregnancy. Our five conclusions are as follows: [1] embryonic secretion of soluble HLA-G protein is variable, [2] secretion of HLA-G is correlated with a higher cleavage rate, [3] secretion of HLA-G is associated with a higher pregnancy rate, [4] HLA-G secretion is a better independent predictor than cleavage rate alone, and [5] the combination of soluble HLA-G detection and high cleavage rate was the best predictor of outcome." @default.
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• W2014239498 date "2005-01-01" @default.
• W2014239498 modified "2023-10-12" @default.
• W2014239498 title "Secretion of human leukocyte antigen-G by human embryos is associated with a higher in vitro fertilization pregnancy rate" @default.
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• W2014239498 doi "https://doi.org/10.1016/j.fertnstert.2004.06.059" @default.
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