FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014239962> ?p ?o ?g. }

• W2014239962 endingPage "290" @default.
• W2014239962 startingPage "283" @default.
• W2014239962 abstract "Clinical application of calcium phosphate cement (CPC; with incorporated polymeric porogens) in an injectable form implicates that loading methods for growth factors are limited. In view of this, the current study evaluated the in vitro and in vivo release kinetics of bone morphogenetic protein-2 (BMP-2) loaded on poly(d,l‐lactic-co-glycolic acid) (PLGA) microparticles (CPC/PLGA), BMP-2 incorporation into the liquid phase of CPC (CPC/liquid), and BMP-2 absorbed to the surface of preset, porous CPC (CPC/surface) as a control via an in vitro release experiment and in vivo using microSPECT imaging with 125I-labeled BMP-2. In addition, the osteoinductive capacity of scaffolds generated via the different BMP-2 loading methods was assessed in a subcutaneous rat model. Additional controls consisted of porous CPC scaffolds (CPC/porous) and CPC/PLGA (CPC/control) without BMP-2 loading. The results revealed that it is feasible to load BMP-2 into CPC via adsorption to PLGA-microparticles or the liquid phase of CPC, which resulted in a similar release profile over the course of 28 days, despite distinct protein distribution patterns. Compared to CPC-scaffolds with surface-loaded BMP-2, these loading methods showed a similar release profile, except for a significantly decreased burst release. As such, the observed osteoinductive capacity for only CPC-scaffolds with surface-loaded BMP-2 is likely to be related to this difference in burst release. It remains unclear to what extent the differential BMP-2 loading methods for injectable CPC can affect the biological response in a bone environment." @default.
• W2014239962 created "2016-06-24" @default.
• W2014239962 creator A5007037502 @default.
• W2014239962 creator A5012764804 @default.
• W2014239962 creator A5038166330 @default.
• W2014239962 creator A5046811601 @default.
• W2014239962 creator A5090135028 @default.
• W2014239962 date "2012-12-01" @default.
• W2014239962 modified "2023-10-01" @default.
• W2014239962 title "Differential loading methods for BMP-2 within injectable calcium phosphate cement" @default.
• W2014239962 cites W1963619461 @default.
• W2014239962 cites W1965672795 @default.
• W2014239962 cites W1971197323 @default.
• W2014239962 cites W1981875126 @default.
• W2014239962 cites W1983452389 @default.
• W2014239962 cites W1989621786 @default.
• W2014239962 cites W2010488113 @default.
• W2014239962 cites W2022782867 @default.
• W2014239962 cites W2032852124 @default.
• W2014239962 cites W2036177694 @default.
• W2014239962 cites W2037923118 @default.
• W2014239962 cites W2041452182 @default.
• W2014239962 cites W2041909276 @default.
• W2014239962 cites W2046925776 @default.
• W2014239962 cites W2051844801 @default.
• W2014239962 cites W2056694125 @default.
• W2014239962 cites W2056813300 @default.
• W2014239962 cites W2059522994 @default.
• W2014239962 cites W2063604302 @default.
• W2014239962 cites W2066440203 @default.
• W2014239962 cites W2068956931 @default.
• W2014239962 cites W2075125957 @default.
• W2014239962 cites W2080580789 @default.
• W2014239962 cites W2087727609 @default.
• W2014239962 cites W2120740945 @default.
• W2014239962 cites W2123714740 @default.
• W2014239962 cites W2126600400 @default.
• W2014239962 cites W2135207107 @default.
• W2014239962 cites W2151124803 @default.
• W2014239962 cites W2158906122 @default.
• W2014239962 cites W2191290986 @default.
• W2014239962 cites W2229247820 @default.
• W2014239962 cites W2231600058 @default.
• W2014239962 doi "https://doi.org/10.1016/j.jconrel.2012.07.007" @default.
• W2014239962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22800584" @default.
• W2014239962 hasPublicationYear "2012" @default.
• W2014239962 type Work @default.
• W2014239962 sameAs 2014239962 @default.
• W2014239962 citedByCount "50" @default.
• W2014239962 countsByYear W20142399622013 @default.
• W2014239962 countsByYear W20142399622014 @default.
• W2014239962 countsByYear W20142399622015 @default.
• W2014239962 countsByYear W20142399622016 @default.
• W2014239962 countsByYear W20142399622017 @default.
• W2014239962 countsByYear W20142399622018 @default.
• W2014239962 countsByYear W20142399622019 @default.
• W2014239962 countsByYear W20142399622020 @default.
• W2014239962 countsByYear W20142399622022 @default.
• W2014239962 countsByYear W20142399622023 @default.
• W2014239962 crossrefType "journal-article" @default.
• W2014239962 hasAuthorship W2014239962A5007037502 @default.
• W2014239962 hasAuthorship W2014239962A5012764804 @default.
• W2014239962 hasAuthorship W2014239962A5038166330 @default.
• W2014239962 hasAuthorship W2014239962A5046811601 @default.
• W2014239962 hasAuthorship W2014239962A5090135028 @default.
• W2014239962 hasConcept C12554922 @default.
• W2014239962 hasConcept C136229726 @default.
• W2014239962 hasConcept C150903083 @default.
• W2014239962 hasConcept C163588942 @default.
• W2014239962 hasConcept C171250308 @default.
• W2014239962 hasConcept C178790620 @default.
• W2014239962 hasConcept C185592680 @default.
• W2014239962 hasConcept C192562407 @default.
• W2014239962 hasConcept C202751555 @default.
• W2014239962 hasConcept C207001950 @default.
• W2014239962 hasConcept C2780165375 @default.
• W2014239962 hasConcept C2993730007 @default.
• W2014239962 hasConcept C30352789 @default.
• W2014239962 hasConcept C43617362 @default.
• W2014239962 hasConcept C519063684 @default.
• W2014239962 hasConcept C55493867 @default.
• W2014239962 hasConcept C71924100 @default.
• W2014239962 hasConcept C86803240 @default.
• W2014239962 hasConceptScore W2014239962C12554922 @default.
• W2014239962 hasConceptScore W2014239962C136229726 @default.
• W2014239962 hasConceptScore W2014239962C150903083 @default.
• W2014239962 hasConceptScore W2014239962C163588942 @default.
• W2014239962 hasConceptScore W2014239962C171250308 @default.
• W2014239962 hasConceptScore W2014239962C178790620 @default.
• W2014239962 hasConceptScore W2014239962C185592680 @default.
• W2014239962 hasConceptScore W2014239962C192562407 @default.
• W2014239962 hasConceptScore W2014239962C202751555 @default.
• W2014239962 hasConceptScore W2014239962C207001950 @default.
• W2014239962 hasConceptScore W2014239962C2780165375 @default.
• W2014239962 hasConceptScore W2014239962C2993730007 @default.
• W2014239962 hasConceptScore W2014239962C30352789 @default.
• W2014239962 hasConceptScore W2014239962C43617362 @default.
• W2014239962 hasConceptScore W2014239962C519063684 @default.

• next