FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014241928> ?p ?o ?g. }

• W2014241928 endingPage "55" @default.
• W2014241928 startingPage "46" @default.
• W2014241928 abstract "Previous studies in experimental models of progressive renal failure have shown that the capacity of antihypertensive drugs to protect glomeruli from sclerosis is often unpredictable from their effect on systemic blood pressure. The present study was undertaken to ascertain whether this systemic blood pressure-independent structure-preserving effect of antihypertensives, particularly angiotensin II converting enzyme inhibitors (ACEI), is confined to the glomerulus or not, as well as whether this effect is mediated via angiotensin II (Ang II). The following experimental drug regimens were used in the rat model of subtotal nephrectomy (sNPX): so-called triple therapy [TRX; a combination of reserpine 5 mg/liter drinking water (DW), hydralazine 80 mg/liter DW and hydrochlorothiazide 25 mg/liter DW], or ACEI (either captopril, CPL, 600 mg/liter DW, enalapril, ENL, 400 mg/liter DW or lisinopril, LSL, 200 mg/liter DW), or a novel Ang II receptor antagonist (Ang IIR, L-158,809, 20 mg/liter DW). These dosages were identified in pilot studies to be the minimum required to control systemic blood pressure in the early phase up to 12 weeks. In addition, a separate group was treated with a higher dose of L-158,809 (80 mg/liter DW) with equipotent systemic pressor effect. Treatment was initiated eight weeks after subtotal nephrectomy following renal biopsy, and animals were sacrificed at 16 weeks. In ACEI treated rats, carotid arterial wall thickening (WT), defined as ratio of media thickening to radius of outer vessel wall, was similar to normal age-matched control (0.073 in all ACEI treated rats, vs. 0.074 in normal control) and significantly less than with TRX (ratio 0.118) or untreated sNPX (0.130). Even more remarkably, coronary arteriole WT in ACEI-treated rats averaged 0.139, a value less than one half and one third of TRX (0.298) and untreated sNPX control (0.388), respectively. Similar results were obtained for mesenteric artery WT. These findings were closely paralleled by changes of glomerular sclerosis. In untreated sNPX control rats, glomerular sclerosis increased from biopsy to autopsy specimens by an average of 458%. Although TRX dampened the degree of increase in sclerosis to on average 212%, this protective effect was far less than that achieved by ACEI. In the latter, sclerosis increased on average only 65% from biopsy to autopsy. Although all ACEIs were more effective than TRX, captopril and lisinopril groups showed greatest benefit at these doses. Ang IIR also protected renal and extrarenal structures with 34% increase of sclerosis index in low dose and WT 0.088, 0.117 and 0.112, respectively in carotid, mesenteric and coronary arteries.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2014241928 created "2016-06-24" @default.
• W2014241928 creator A5024863462 @default.
• W2014241928 creator A5031318134 @default.
• W2014241928 creator A5034261204 @default.
• W2014241928 creator A5055495459 @default.
• W2014241928 creator A5083183689 @default.
• W2014241928 creator A5087357193 @default.
• W2014241928 date "1992-07-01" @default.
• W2014241928 modified "2023-10-16" @default.
• W2014241928 title "Blood pressure-independent effect of angiotensin inhibition on vascular lesions of chronic renal failure" @default.
• W2014241928 cites W1466908809 @default.
• W2014241928 cites W1575840121 @default.
• W2014241928 cites W1977964839 @default.
• W2014241928 cites W1978350809 @default.
• W2014241928 cites W1980392642 @default.
• W2014241928 cites W1989883100 @default.
• W2014241928 cites W2002225053 @default.
• W2014241928 cites W2003423004 @default.
• W2014241928 cites W2004043215 @default.
• W2014241928 cites W2005348762 @default.
• W2014241928 cites W2018401813 @default.
• W2014241928 cites W2027785852 @default.
• W2014241928 cites W2031534703 @default.
• W2014241928 cites W2031810169 @default.
• W2014241928 cites W2043184584 @default.
• W2014241928 cites W2053097440 @default.
• W2014241928 cites W2053181724 @default.
• W2014241928 cites W2061166866 @default.
• W2014241928 cites W2063928700 @default.
• W2014241928 cites W2065860622 @default.
• W2014241928 cites W2070730749 @default.
• W2014241928 cites W2077751503 @default.
• W2014241928 cites W2084279444 @default.
• W2014241928 cites W2087375731 @default.
• W2014241928 cites W2092389955 @default.
• W2014241928 cites W2111780029 @default.
• W2014241928 cites W2117594247 @default.
• W2014241928 cites W2124634432 @default.
• W2014241928 cites W2136898798 @default.
• W2014241928 cites W2161639624 @default.
• W2014241928 cites W2406813806 @default.
• W2014241928 cites W2462703090 @default.
• W2014241928 doi "https://doi.org/10.1038/ki.1992.259" @default.
• W2014241928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1635354" @default.
• W2014241928 hasPublicationYear "1992" @default.
• W2014241928 type Work @default.
• W2014241928 sameAs 2014241928 @default.
• W2014241928 citedByCount "161" @default.
• W2014241928 countsByYear W20142419282012 @default.
• W2014241928 countsByYear W20142419282013 @default.
• W2014241928 countsByYear W20142419282014 @default.
• W2014241928 countsByYear W20142419282015 @default.
• W2014241928 countsByYear W20142419282016 @default.
• W2014241928 countsByYear W20142419282017 @default.
• W2014241928 countsByYear W20142419282018 @default.
• W2014241928 countsByYear W20142419282020 @default.
• W2014241928 countsByYear W20142419282021 @default.
• W2014241928 countsByYear W20142419282022 @default.
• W2014241928 crossrefType "journal-article" @default.
• W2014241928 hasAuthorship W2014241928A5024863462 @default.
• W2014241928 hasAuthorship W2014241928A5031318134 @default.
• W2014241928 hasAuthorship W2014241928A5034261204 @default.
• W2014241928 hasAuthorship W2014241928A5055495459 @default.
• W2014241928 hasAuthorship W2014241928A5083183689 @default.
• W2014241928 hasAuthorship W2014241928A5087357193 @default.
• W2014241928 hasBestOaLocation W20142419281 @default.
• W2014241928 hasConcept C126322002 @default.
• W2014241928 hasConcept C126894567 @default.
• W2014241928 hasConcept C134018914 @default.
• W2014241928 hasConcept C176674119 @default.
• W2014241928 hasConcept C27016395 @default.
• W2014241928 hasConcept C2775940317 @default.
• W2014241928 hasConcept C2777880890 @default.
• W2014241928 hasConcept C2779611605 @default.
• W2014241928 hasConcept C2780361556 @default.
• W2014241928 hasConcept C2780521442 @default.
• W2014241928 hasConcept C2908929049 @default.
• W2014241928 hasConcept C71924100 @default.
• W2014241928 hasConcept C84393581 @default.
• W2014241928 hasConceptScore W2014241928C126322002 @default.
• W2014241928 hasConceptScore W2014241928C126894567 @default.
• W2014241928 hasConceptScore W2014241928C134018914 @default.
• W2014241928 hasConceptScore W2014241928C176674119 @default.
• W2014241928 hasConceptScore W2014241928C27016395 @default.
• W2014241928 hasConceptScore W2014241928C2775940317 @default.
• W2014241928 hasConceptScore W2014241928C2777880890 @default.
• W2014241928 hasConceptScore W2014241928C2779611605 @default.
• W2014241928 hasConceptScore W2014241928C2780361556 @default.
• W2014241928 hasConceptScore W2014241928C2780521442 @default.
• W2014241928 hasConceptScore W2014241928C2908929049 @default.
• W2014241928 hasConceptScore W2014241928C71924100 @default.
• W2014241928 hasConceptScore W2014241928C84393581 @default.
• W2014241928 hasIssue "1" @default.
• W2014241928 hasLocation W20142419281 @default.
• W2014241928 hasLocation W20142419282 @default.
• W2014241928 hasOpenAccess W2014241928 @default.
• W2014241928 hasPrimaryLocation W20142419281 @default.

• next