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- W2014242302 abstract "Carbon exchange in the Krebs cycle may result in underestimation of substrate oxidation measured with 13C-labeled substrates, since carbon labeled in position 2 of acetyl-coenzyme A (CoA) could be incorporated into glucose (via gluconeogenesis) and glutamine. Five healthy volunteers were therefore infused with [1-13C] and [2-13C] acetate at a rate of 0.5 μmol · kg−1 · min−1 for 165 minutes on two different occasions in randomized order. Whole body acetate turnover did not differ between the two tracers: 7.9 ± 0.3 and 7.5 ± 0.6 μmol · kg−1 · min−1 (nonsignificant [NS]) for [1-13C] and [2-13C] acetate, respectively. Isotopic 13C enrichment was higher in expired CO2 (0.177 ± 0.021 v 0.089 ± 0.009 atom percent excess [APE], P < .01) and lower in glucose (0.074 ± 0.017 v 0.291 ± 0.061 mole percent excess [MPE], P < .01) for [1-13C] acetate compared with [2-13C] acetate, respectively, at the end of the infusions. Glutamine isotopic enrichment was slightly but not significantly higher when infusing [1-13C] acetate versus [2-13C] acetate (0.348 ± 0.038 v 0.495 ± 0.069 MPE, NS, respectively). At the end of the experiment, the recovery of 13CO2 from [1-13C] acetate was 44.8% ± 2.7%, and from [2-13C] acetate, 22.6% ± 1.3%. A significant correlation was observed between the differences in 13C enrichment of CO2 for the two tracers and glucose (ΔCO2 = 0.424 · Δglucose + 0.001, R2 = .9856, P = .0007) or glutamine (ΔCO2 = 0.621 · Δglutamine + 0.004, R2 = .9573, P = .0038) during the infusion. These results suggest that (1) although gluconeogenesis appears to be more responsible than glutamine for the differential recovery of [2-13C] versus [1-13C] acetate, other secondary pathways are probably also implicated; and (2) different recovery correction factors should be applied when measuring substrate oxidation with a stable isotope tracer depending on the expected position of 13C in acetyl-CoA." @default.
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- W2014242302 date "1998-05-01" @default.
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- W2014242302 title "Role of glucose and glutamine synthesis in the differential recovery of 13CO2 from infused [2-13C] versus [1-13C] acetate" @default.
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- W2014242302 doi "https://doi.org/10.1016/s0026-0495(98)90238-4" @default.
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