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- W2014242938 abstract "Abstract Single i.p. injections of 6-hydroxylaminopurine (HAP) at doses ranging from 200 to 900 mg kg of maternal body weight given to the pregnant Wistar rat on day 11 or 12 of gestation produced malformations which included cleft palate, micrognathia and deformed appendages and tail in fetuses that survived to day 21 of gestation. No malformations were observed in fetuses at 21 days with any of the doses (50–600 mg kg ) given on day 9 or 10 of gestation. A single dose of 500 mg kg of inosine provided complete protection against fetal malformations produced by a single dose of 500 mg kg of HAP at 21 days when the two compounds were given at zero time and up to 5 min apart to the 12-day pregnant rat. Only partial protection occurred with lower doses of inosine (200–400 mg kg ), with all doses of hypoxanthine (50–1000 mg kg ) and adenine (50–250 mg kg ) as well as with increasing time intervals (10–120 min) between administration of equal amounts (500 mg kg ) of HAP and inosine." @default.
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- W2014242938 date "1969-05-01" @default.
- W2014242938 modified "2023-09-25" @default.
- W2014242938 title "Teratogenic effects of 6-hydroxylaminopurine in the rat—protection by inosine" @default.
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- W2014242938 doi "https://doi.org/10.1016/0006-2952(69)90118-x" @default.
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