Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014243915> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2014243915 endingPage "89" @default.
- W2014243915 startingPage "81" @default.
- W2014243915 abstract "The objectives of this research were to determine the partitioning properties and the solution stability of the [Nle4-DPhe7]α-MSH analog called Melanotan-I (MT-I). The apparent partition coefficients (APC) were determined in two solvent systems, i.e. octanol-buffer and isooctane-buffer in order to calculate Δ Log P.C. (partition coefficient) values. The Δ Log P.C. values at pH 2.5 and 7.4 were −0.307 and −0.409, respectively. The solution stability of MT-I was determined by accelerated stability studies at 70°, 80° and 87°C at pH 7.4 and ionic strength (μ) of 0.17. The energy of activation (Ea) was calculated to be 15.83 kcal/mol, resulting in an estimated shelf life of 40 days at room temperature. From the pH-rate profile, MT-I was observed to be relatively stable under acidic conditions and exhibited greater degradation under basic conditions. Both ionic strength (μ = 0.15 to 1.5, at 0.05 M buffer concentration) and phosphate buffer concentration (0.1–0.5 M, μ = 1.5) at pH 7.3 and 80°C had no effect on the degradation kinetics of MT-I." @default.
- W2014243915 created "2016-06-24" @default.
- W2014243915 creator A5001352950 @default.
- W2014243915 creator A5017181000 @default.
- W2014243915 creator A5022726638 @default.
- W2014243915 creator A5024232182 @default.
- W2014243915 creator A5063883202 @default.
- W2014243915 date "1996-06-17" @default.
- W2014243915 modified "2023-09-25" @default.
- W2014243915 title "Partitioning properties and degradation kinetics of the [Nle4-DPhe7]α-MSH analog Melanotan-I (MT-I)" @default.
- W2014243915 cites W1498354276 @default.
- W2014243915 cites W2016339097 @default.
- W2014243915 cites W2073025812 @default.
- W2014243915 cites W2168842279 @default.
- W2014243915 doi "https://doi.org/10.1016/0378-5173(95)04394-2" @default.
- W2014243915 hasPublicationYear "1996" @default.
- W2014243915 type Work @default.
- W2014243915 sameAs 2014243915 @default.
- W2014243915 citedByCount "1" @default.
- W2014243915 crossrefType "journal-article" @default.
- W2014243915 hasAuthorship W2014243915A5001352950 @default.
- W2014243915 hasAuthorship W2014243915A5017181000 @default.
- W2014243915 hasAuthorship W2014243915A5022726638 @default.
- W2014243915 hasAuthorship W2014243915A5024232182 @default.
- W2014243915 hasAuthorship W2014243915A5063883202 @default.
- W2014243915 hasConcept C121332964 @default.
- W2014243915 hasConcept C13965031 @default.
- W2014243915 hasConcept C147789679 @default.
- W2014243915 hasConcept C148898269 @default.
- W2014243915 hasConcept C178790620 @default.
- W2014243915 hasConcept C184651966 @default.
- W2014243915 hasConcept C185592680 @default.
- W2014243915 hasConcept C187428577 @default.
- W2014243915 hasConcept C192552737 @default.
- W2014243915 hasConcept C2776226600 @default.
- W2014243915 hasConcept C2777132085 @default.
- W2014243915 hasConcept C2779679103 @default.
- W2014243915 hasConcept C41008148 @default.
- W2014243915 hasConcept C43617362 @default.
- W2014243915 hasConcept C62520636 @default.
- W2014243915 hasConcept C76155785 @default.
- W2014243915 hasConcept C95121573 @default.
- W2014243915 hasConceptScore W2014243915C121332964 @default.
- W2014243915 hasConceptScore W2014243915C13965031 @default.
- W2014243915 hasConceptScore W2014243915C147789679 @default.
- W2014243915 hasConceptScore W2014243915C148898269 @default.
- W2014243915 hasConceptScore W2014243915C178790620 @default.
- W2014243915 hasConceptScore W2014243915C184651966 @default.
- W2014243915 hasConceptScore W2014243915C185592680 @default.
- W2014243915 hasConceptScore W2014243915C187428577 @default.
- W2014243915 hasConceptScore W2014243915C192552737 @default.
- W2014243915 hasConceptScore W2014243915C2776226600 @default.
- W2014243915 hasConceptScore W2014243915C2777132085 @default.
- W2014243915 hasConceptScore W2014243915C2779679103 @default.
- W2014243915 hasConceptScore W2014243915C41008148 @default.
- W2014243915 hasConceptScore W2014243915C43617362 @default.
- W2014243915 hasConceptScore W2014243915C62520636 @default.
- W2014243915 hasConceptScore W2014243915C76155785 @default.
- W2014243915 hasConceptScore W2014243915C95121573 @default.
- W2014243915 hasIssue "1-2" @default.
- W2014243915 hasLocation W20142439151 @default.
- W2014243915 hasOpenAccess W2014243915 @default.
- W2014243915 hasPrimaryLocation W20142439151 @default.
- W2014243915 hasRelatedWork W1999669358 @default.
- W2014243915 hasRelatedWork W2069225662 @default.
- W2014243915 hasRelatedWork W2115509089 @default.
- W2014243915 hasRelatedWork W2117280257 @default.
- W2014243915 hasRelatedWork W2302346809 @default.
- W2014243915 hasRelatedWork W2365347044 @default.
- W2014243915 hasRelatedWork W2371342163 @default.
- W2014243915 hasRelatedWork W2379396254 @default.
- W2014243915 hasRelatedWork W2385979486 @default.
- W2014243915 hasRelatedWork W2393453980 @default.
- W2014243915 hasVolume "135" @default.
- W2014243915 isParatext "false" @default.
- W2014243915 isRetracted "false" @default.
- W2014243915 magId "2014243915" @default.
- W2014243915 workType "article" @default.