Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014246135> ?p ?o ?g. }
- W2014246135 endingPage "2783" @default.
- W2014246135 startingPage "2775" @default.
- W2014246135 abstract "Ferritin light chain (FTL) reduces the free iron concentration by forming ferritin complexes with ferritin heavy chain (FTH). Thus, FTL competes with the Fenton reaction by acting as an antioxidant. In the present study, we determined that FTL influences the lipopolysaccharide (LPS)-induced inflammatory response. FTL protein expression was regulated by LPS stimulation in RAW264.7 cells. To investigate the role of FTL in LPS-activated murine macrophages, we established stable FTL-expressing cells and used shRNA to silence FTL expression in RAW264.7 cells. Overexpression of FTL significantly decreased the LPS-induced production of tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β), nitric oxide (NO) and prostaglandin E2 (PGE2). Additionally, overexpression of FTL decreased the LPS-induced increase of the intracellular labile iron pool (LIP) and reactive oxygen species (ROS). Moreover, FTL overexpression suppressed the LPS-induced activation of MAPKs and nuclear factor-κB (NF-κB). In contrast, knockdown of FTL by shRNA showed the reverse effects. Therefore, our results indicate that FTL plays an anti-inflammatory role in response to LPS in murine macrophages and may have therapeutic potential for treating inflammatory diseases." @default.
- W2014246135 created "2016-06-24" @default.
- W2014246135 creator A5001015432 @default.
- W2014246135 creator A5016806891 @default.
- W2014246135 creator A5018070776 @default.
- W2014246135 creator A5032829757 @default.
- W2014246135 creator A5035591504 @default.
- W2014246135 creator A5041849605 @default.
- W2014246135 creator A5042795221 @default.
- W2014246135 creator A5055345054 @default.
- W2014246135 creator A5064672242 @default.
- W2014246135 creator A5065291902 @default.
- W2014246135 creator A5065292406 @default.
- W2014246135 creator A5073501391 @default.
- W2014246135 creator A5089343090 @default.
- W2014246135 date "2014-11-01" @default.
- W2014246135 modified "2023-10-18" @default.
- W2014246135 title "The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages" @default.
- W2014246135 cites W1549816609 @default.
- W2014246135 cites W1558349166 @default.
- W2014246135 cites W1781350855 @default.
- W2014246135 cites W1968134244 @default.
- W2014246135 cites W1982826106 @default.
- W2014246135 cites W1986662693 @default.
- W2014246135 cites W1988924112 @default.
- W2014246135 cites W2001066067 @default.
- W2014246135 cites W2010100852 @default.
- W2014246135 cites W2012992792 @default.
- W2014246135 cites W2013961558 @default.
- W2014246135 cites W2016146035 @default.
- W2014246135 cites W2016762244 @default.
- W2014246135 cites W2020712752 @default.
- W2014246135 cites W2022673236 @default.
- W2014246135 cites W2024322742 @default.
- W2014246135 cites W2026403400 @default.
- W2014246135 cites W2027262540 @default.
- W2014246135 cites W2032849462 @default.
- W2014246135 cites W2033538297 @default.
- W2014246135 cites W2038026059 @default.
- W2014246135 cites W2041016616 @default.
- W2014246135 cites W2041019415 @default.
- W2014246135 cites W2043579356 @default.
- W2014246135 cites W2049233126 @default.
- W2014246135 cites W2057626412 @default.
- W2014246135 cites W2057810394 @default.
- W2014246135 cites W2068006559 @default.
- W2014246135 cites W2069028439 @default.
- W2014246135 cites W2069096130 @default.
- W2014246135 cites W2073194643 @default.
- W2014246135 cites W2078205387 @default.
- W2014246135 cites W2081323829 @default.
- W2014246135 cites W2082678926 @default.
- W2014246135 cites W2084674399 @default.
- W2014246135 cites W2089767083 @default.
- W2014246135 cites W2091792491 @default.
- W2014246135 cites W2094837026 @default.
- W2014246135 cites W2099070400 @default.
- W2014246135 cites W2110322630 @default.
- W2014246135 cites W2112841789 @default.
- W2014246135 cites W2135735522 @default.
- W2014246135 cites W2138590480 @default.
- W2014246135 cites W2142772502 @default.
- W2014246135 cites W2156336082 @default.
- W2014246135 cites W2158115535 @default.
- W2014246135 cites W2164394541 @default.
- W2014246135 cites W2168620413 @default.
- W2014246135 cites W2171028948 @default.
- W2014246135 cites W2182320484 @default.
- W2014246135 cites W4248389956 @default.
- W2014246135 doi "https://doi.org/10.1016/j.bbamcr.2014.06.015" @default.
- W2014246135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24983770" @default.
- W2014246135 hasPublicationYear "2014" @default.
- W2014246135 type Work @default.
- W2014246135 sameAs 2014246135 @default.
- W2014246135 citedByCount "45" @default.
- W2014246135 countsByYear W20142461352015 @default.
- W2014246135 countsByYear W20142461352016 @default.
- W2014246135 countsByYear W20142461352018 @default.
- W2014246135 countsByYear W20142461352019 @default.
- W2014246135 countsByYear W20142461352020 @default.
- W2014246135 countsByYear W20142461352021 @default.
- W2014246135 countsByYear W20142461352022 @default.
- W2014246135 countsByYear W20142461352023 @default.
- W2014246135 crossrefType "journal-article" @default.
- W2014246135 hasAuthorship W2014246135A5001015432 @default.
- W2014246135 hasAuthorship W2014246135A5016806891 @default.
- W2014246135 hasAuthorship W2014246135A5018070776 @default.
- W2014246135 hasAuthorship W2014246135A5032829757 @default.
- W2014246135 hasAuthorship W2014246135A5035591504 @default.
- W2014246135 hasAuthorship W2014246135A5041849605 @default.
- W2014246135 hasAuthorship W2014246135A5042795221 @default.
- W2014246135 hasAuthorship W2014246135A5055345054 @default.
- W2014246135 hasAuthorship W2014246135A5064672242 @default.
- W2014246135 hasAuthorship W2014246135A5065291902 @default.
- W2014246135 hasAuthorship W2014246135A5065292406 @default.
- W2014246135 hasAuthorship W2014246135A5073501391 @default.
- W2014246135 hasAuthorship W2014246135A5089343090 @default.
- W2014246135 hasBestOaLocation W20142461351 @default.