FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014252415> ?p ?o ?g. }

• W2014252415 endingPage "e1003394" @default.
• W2014252415 startingPage "e1003394" @default.
• W2014252415 abstract "The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the desire to understand fundamental phenomena, and second, its vast practical importance. Allostery is at play in all processes in the living cell, and increasingly in drug discovery. Many models have been successfully formulated, and are able to describe allostery even in the absence of a detailed structural mechanism. However, conceptual schemes designed to qualitatively explain allosteric mechanisms usually lack a quantitative mathematical model, and are unable to link its thermodynamic and structural foundations. This hampers insight into oncogenic mutations in cancer progression and biased agonists' actions. Here, we describe how allostery works from three different standpoints: thermodynamics, free energy landscape of population shift, and structure; all with exactly the same allosteric descriptors. This results in a unified view which not only clarifies the elusive allosteric mechanism but also provides structural grasp of agonist-mediated signaling pathways, and guides allosteric drug discovery. Of note, the unified view reasons that allosteric coupling (or communication) does not determine the allosteric efficacy; however, a communication channel is what makes potential binding sites allosteric." @default.
• W2014252415 created "2016-06-24" @default.
• W2014252415 creator A5020262392 @default.
• W2014252415 creator A5025357844 @default.
• W2014252415 date "2014-02-06" @default.
• W2014252415 modified "2023-09-30" @default.
• W2014252415 title "A Unified View of “How Allostery Works”" @default.
• W2014252415 cites W1594547339 @default.
• W2014252415 cites W1965835906 @default.
• W2014252415 cites W1969563735 @default.
• W2014252415 cites W1969939692 @default.
• W2014252415 cites W1972919297 @default.
• W2014252415 cites W1976266427 @default.
• W2014252415 cites W1976738153 @default.
• W2014252415 cites W1983165588 @default.
• W2014252415 cites W1986795645 @default.
• W2014252415 cites W1987582289 @default.
• W2014252415 cites W1988837867 @default.
• W2014252415 cites W1992784105 @default.
• W2014252415 cites W1998093640 @default.
• W2014252415 cites W2007832948 @default.
• W2014252415 cites W2009123297 @default.
• W2014252415 cites W2011669324 @default.
• W2014252415 cites W2014038272 @default.
• W2014252415 cites W2016386715 @default.
• W2014252415 cites W2020622784 @default.
• W2014252415 cites W2024620705 @default.
• W2014252415 cites W2026911129 @default.
• W2014252415 cites W2029745930 @default.
• W2014252415 cites W2030368884 @default.
• W2014252415 cites W2037694981 @default.
• W2014252415 cites W2037787959 @default.
• W2014252415 cites W2041205020 @default.
• W2014252415 cites W2042239308 @default.
• W2014252415 cites W2042964041 @default.
• W2014252415 cites W2045143386 @default.
• W2014252415 cites W2049682677 @default.
• W2014252415 cites W2049843026 @default.
• W2014252415 cites W2050643839 @default.
• W2014252415 cites W2053004995 @default.
• W2014252415 cites W2053717973 @default.
• W2014252415 cites W2058240476 @default.
• W2014252415 cites W2075702662 @default.
• W2014252415 cites W2083975423 @default.
• W2014252415 cites W2087565057 @default.
• W2014252415 cites W2088311925 @default.
• W2014252415 cites W2090272634 @default.
• W2014252415 cites W2094795801 @default.
• W2014252415 cites W2096345281 @default.
• W2014252415 cites W2099297532 @default.
• W2014252415 cites W2105850024 @default.
• W2014252415 cites W2106777560 @default.
• W2014252415 cites W2110810762 @default.
• W2014252415 cites W2111373319 @default.
• W2014252415 cites W2112907786 @default.
• W2014252415 cites W2113030357 @default.
• W2014252415 cites W2115152262 @default.
• W2014252415 cites W2118770079 @default.
• W2014252415 cites W2124676068 @default.
• W2014252415 cites W2141346349 @default.
• W2014252415 cites W2142544064 @default.
• W2014252415 cites W2147466870 @default.
• W2014252415 cites W2154279541 @default.
• W2014252415 cites W2158150436 @default.
• W2014252415 cites W2159756091 @default.
• W2014252415 cites W2336542886 @default.
• W2014252415 cites W3025891904 @default.
• W2014252415 cites W30334872 @default.
• W2014252415 doi "https://doi.org/10.1371/journal.pcbi.1003394" @default.
• W2014252415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3916236" @default.
• W2014252415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24516370" @default.
• W2014252415 hasPublicationYear "2014" @default.
• W2014252415 type Work @default.
• W2014252415 sameAs 2014252415 @default.
• W2014252415 citedByCount "324" @default.
• W2014252415 countsByYear W20142524152014 @default.
• W2014252415 countsByYear W20142524152015 @default.
• W2014252415 countsByYear W20142524152016 @default.
• W2014252415 countsByYear W20142524152017 @default.
• W2014252415 countsByYear W20142524152018 @default.
• W2014252415 countsByYear W20142524152019 @default.
• W2014252415 countsByYear W20142524152020 @default.
• W2014252415 countsByYear W20142524152021 @default.
• W2014252415 countsByYear W20142524152022 @default.
• W2014252415 countsByYear W20142524152023 @default.
• W2014252415 crossrefType "journal-article" @default.
• W2014252415 hasAuthorship W2014252415A5020262392 @default.
• W2014252415 hasAuthorship W2014252415A5025357844 @default.
• W2014252415 hasBestOaLocation W20142524151 @default.
• W2014252415 hasConcept C111472728 @default.
• W2014252415 hasConcept C138885662 @default.
• W2014252415 hasConcept C15744967 @default.
• W2014252415 hasConcept C166342909 @default.
• W2014252415 hasConcept C181199279 @default.
• W2014252415 hasConcept C188147891 @default.
• W2014252415 hasConcept C41008148 @default.
• W2014252415 hasConcept C55493867 @default.
• W2014252415 hasConcept C70721500 @default.

• next