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- W2014253198 abstract "This study describes a micro electrode array (MEA)‐based biosensor for taste transduction using heterologous expressed taste polycystic kidney disease‐like (PKD) channels as molecular sensors. Taste PKD1L3/2L1 channels were expressed on the plasma membrane of human embryo kidney (HEK)‐293 cells [1]. Then the cells were cultured on the surface of MEA chip [2] to record the responses of PKD channels to sour stimulations by monitoring membrane potential. The results indicate this MEA‐based biosensor can record the special off‐responses of PKD channels to sour stimulation in a non‐invasive manner for a long term. It may provide an alternative tool for the research of taste transduction, especially for the characterization of taste ion channels." @default.
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- W2014253198 date "2011-01-01" @default.
- W2014253198 modified "2023-09-25" @default.
- W2014253198 title "A PKD Channel-based Biosensor for Taste Transduction" @default.
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- W2014253198 doi "https://doi.org/10.1063/1.3626321" @default.
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