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- W2014254803 abstract "Fifty-three patients with non—insulin-dependent diabetes mellitus and hypertension were randomly treated with extended-release felodipine 10 mg/d, amlodipine 10 mg/d, or placebo for 6 weeks. Mean clinostatic systolic and diastolic blood pressures were significantly reduced from baseline with both drug treatments (P < 0.0001), whereas placebo affected only systolic pressure. Neither felodipine nor amlodipine treatment led to any significant change in glucose tolerance (as measured by using the oral glucose tolerance test), C-peptide secretion, fructosamine, or glycated hemoglobin A1c levels. Similarly, neither treatment appeared to increase triglyceride levels, total cholesterol levels, or its fractions. All safety parameters remained stable during the study. There was no significant trend in electrocardiogram (ECG) variations for any of the treatments, but one patient in the amlodipine group showed ECG signs compatible with acute myocardial infarction. These data suggest that in diabetic hypertensive patients, both felodipine and amlodipine have a neutral effect on glucose and lipid metabolism while retaining their hemodynamic efficacy. Therefore, their use as first-step antihypertensive therapies can be recommended in such patients." @default.
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- W2014254803 date "1995-10-01" @default.
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- W2014254803 title "The effects of felodipine and amlodipine on glucose and lipid metabolism in patients affected by non—insulin-dependent diabetes mellitus and hypertension: a comparative, randomized, parallel-group study" @default.
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- W2014254803 doi "https://doi.org/10.1016/0011-393x(95)85111-9" @default.
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