Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014254811> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2014254811 endingPage "11" @default.
- W2014254811 startingPage "7" @default.
- W2014254811 abstract "Chicken liver mevalonate 5-diphosphate decar☐ylase (ATP:(R)-5-diphosphomevalonate car☐y-lyase (dehydrating), EC 4.1.1.33) is inactivated by methylmethanethiosulfonate and 5,5′-dithiobis(2-nitrobenzoate). The presence of the substrates ATP or mevalonate 5-diphosphate protect very effectively against inactivation. The inactivation is second order with respect to methylmethanethiosulfonate, with an inactivation rate constant of (7.6 ± 0.1) · 10−5 μM−2 ·s−1, implying that the modifier may be reacting with more than one thiol in the enzyme. The enzyme is also inactivated by a number of dithiol-specific reagents, suggesting the presence of a functional dithiol. The determined pKapp values for enzyme modification by methyl methanethiosulfonate and phenylarsine oxide are 7.3 ± 0.1 and 7.6 ± 0.3, respectively. From the data presented, it is concluded that the enzyme posseses a functional dithiol that is important for substrate binding." @default.
- W2014254811 created "2016-06-24" @default.
- W2014254811 creator A5019370945 @default.
- W2014254811 creator A5054781000 @default.
- W2014254811 creator A5087360714 @default.
- W2014254811 date "1989-01-01" @default.
- W2014254811 modified "2023-09-24" @default.
- W2014254811 title "Inactivation of chicken liver mevalonate 5-diphosphate decar☐ylase by sulfhydryl-directed reagents: evidence of a functional dithiol" @default.
- W2014254811 cites W1652532525 @default.
- W2014254811 cites W1819324606 @default.
- W2014254811 cites W189390795 @default.
- W2014254811 cites W1979741958 @default.
- W2014254811 cites W1981948576 @default.
- W2014254811 cites W1994006719 @default.
- W2014254811 cites W1994763178 @default.
- W2014254811 cites W2000101364 @default.
- W2014254811 cites W2001542732 @default.
- W2014254811 cites W2006370393 @default.
- W2014254811 cites W2016634320 @default.
- W2014254811 cites W2034210911 @default.
- W2014254811 cites W2059030178 @default.
- W2014254811 cites W2063017186 @default.
- W2014254811 cites W2073067468 @default.
- W2014254811 cites W2076337455 @default.
- W2014254811 cites W2080052515 @default.
- W2014254811 cites W2180765815 @default.
- W2014254811 cites W2403297264 @default.
- W2014254811 cites W2883428738 @default.
- W2014254811 cites W31365474 @default.
- W2014254811 doi "https://doi.org/10.1016/0167-4838(89)90055-1" @default.
- W2014254811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2909257" @default.
- W2014254811 hasPublicationYear "1989" @default.
- W2014254811 type Work @default.
- W2014254811 sameAs 2014254811 @default.
- W2014254811 citedByCount "7" @default.
- W2014254811 countsByYear W20142548112013 @default.
- W2014254811 crossrefType "journal-article" @default.
- W2014254811 hasAuthorship W2014254811A5019370945 @default.
- W2014254811 hasAuthorship W2014254811A5054781000 @default.
- W2014254811 hasAuthorship W2014254811A5087360714 @default.
- W2014254811 hasConcept C178790620 @default.
- W2014254811 hasConcept C181199279 @default.
- W2014254811 hasConcept C185592680 @default.
- W2014254811 hasConcept C18903297 @default.
- W2014254811 hasConcept C2776617069 @default.
- W2014254811 hasConcept C2777289219 @default.
- W2014254811 hasConcept C2781161309 @default.
- W2014254811 hasConcept C2781324293 @default.
- W2014254811 hasConcept C40875361 @default.
- W2014254811 hasConcept C55493867 @default.
- W2014254811 hasConcept C86803240 @default.
- W2014254811 hasConceptScore W2014254811C178790620 @default.
- W2014254811 hasConceptScore W2014254811C181199279 @default.
- W2014254811 hasConceptScore W2014254811C185592680 @default.
- W2014254811 hasConceptScore W2014254811C18903297 @default.
- W2014254811 hasConceptScore W2014254811C2776617069 @default.
- W2014254811 hasConceptScore W2014254811C2777289219 @default.
- W2014254811 hasConceptScore W2014254811C2781161309 @default.
- W2014254811 hasConceptScore W2014254811C2781324293 @default.
- W2014254811 hasConceptScore W2014254811C40875361 @default.
- W2014254811 hasConceptScore W2014254811C55493867 @default.
- W2014254811 hasConceptScore W2014254811C86803240 @default.
- W2014254811 hasIssue "1" @default.
- W2014254811 hasLocation W20142548111 @default.
- W2014254811 hasLocation W20142548112 @default.
- W2014254811 hasOpenAccess W2014254811 @default.
- W2014254811 hasPrimaryLocation W20142548111 @default.
- W2014254811 hasRelatedWork W1845860633 @default.
- W2014254811 hasRelatedWork W1966418295 @default.
- W2014254811 hasRelatedWork W1976753839 @default.
- W2014254811 hasRelatedWork W1980193768 @default.
- W2014254811 hasRelatedWork W2005098583 @default.
- W2014254811 hasRelatedWork W2014116614 @default.
- W2014254811 hasRelatedWork W2014254811 @default.
- W2014254811 hasRelatedWork W2080497325 @default.
- W2014254811 hasRelatedWork W2953155228 @default.
- W2014254811 hasRelatedWork W2020331349 @default.
- W2014254811 hasVolume "994" @default.
- W2014254811 isParatext "false" @default.
- W2014254811 isRetracted "false" @default.
- W2014254811 magId "2014254811" @default.
- W2014254811 workType "article" @default.