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• W2014256493 abstract "The compaction of gene-size T4 DNA induced by the action of silica nanoparticles (10–100 nm diameter), the surfaces of which were modified to various degrees by a 3-aminopropylsilyl groups, was monitored by a fluorescent microscope in an aqueous solution. It was found that DNA compaction was facilitated by mono- and divalent cations such as Na+, K+, Mg2+, and Ca2+. This promotion by cations was the result of charge-neutralization of DNA and was more remarkable in compaction by histone-size nanoparticles (10 nm) than in that by larger ones (>15 nm). Divalent metal ions were more effective at promoting compaction due to their greater charge-neutralizing character, but a quaternary diammonium derivative of 1,3-propanediamine deactivated DNA compaction by 10-nm nanoparticles. Although metal ions binding to DNA can reduce electrostatic tension on DNA and provide flexibility to create a DNA loop with a small diameter, such ammonium dication does not make DNA sufficiently flexible." @default.
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• W2014256493 date "2010-06-15" @default.
• W2014256493 modified "2023-09-25" @default.
• W2014256493 title "Roles of Mono- and Divalent Cations in DNA Compaction Induced by Histone-Mimic Nanoparticles" @default.
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• W2014256493 doi "https://doi.org/10.1246/bcsj.20090324" @default.
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