Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014258144> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2014258144 abstract "Oxygen-derived radicals and cytokines are known to play key roles in cellular inflammation accompanying allergic lung disease. Using a well-characterized guinea pig model of pulmonary ovalbumin (OA) hypersensitivity, we studied lipid peroxidation and endogenous antioxidant reserve in bronchoalveolar lung fluid (BAL) following a severe pulmonary allergic reaction. Since TNF-alpha is known to be involved in oxygen radical generation, we also examined TNF production in response to antigen challenge. By 24 hr after antigen challenge, the number of eosinophils in BAL was increased 3.5-fold compared with nonsensitized but challenged control animals. Immunohistochemical evaluation of BAL cells, employing a polyclonal antibody to murine TNF-alpha, demonstrated the presence of TNF in eosinophils. A 2.4-fold higher concentration of lipid peroxidation products was found in BAL fluid of sensitized and challenged vs nonsensitized, challenged guinea pigs (p < 0.05). Endogenous antioxidant levels were lower in the BAL fluid of the sensitized, challenged guinea pigs. The concentration of the major lipid-soluble antioxidant, vitamin E, was 8.7-fold lower than that in nonsensitized controls (p < 0.001) and the endogenous reserve of water-soluble antioxidants (thiols and ascorbic acid) was decreased 4-fold from that of control animals (p < 0.02). These results indicate an antioxidant/prooxidant imbalance associated with an allergic pulmonary episode." @default.
- W2014258144 created "2016-06-24" @default.
- W2014258144 creator A5015583050 @default.
- W2014258144 creator A5038216324 @default.
- W2014258144 creator A5049450190 @default.
- W2014258144 creator A5069406228 @default.
- W2014258144 date "1995-05-01" @default.
- W2014258144 modified "2023-09-26" @default.
- W2014258144 title "Increased Lipid Peroxidation and Decreased Antioxidants in Lungs of Guinea Pigs Following an Allergic Pulmonary Response" @default.
- W2014258144 doi "https://doi.org/10.1006/taap.1995.1088" @default.
- W2014258144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7747287" @default.
- W2014258144 hasPublicationYear "1995" @default.
- W2014258144 type Work @default.
- W2014258144 sameAs 2014258144 @default.
- W2014258144 citedByCount "29" @default.
- W2014258144 countsByYear W20142581442013 @default.
- W2014258144 countsByYear W20142581442014 @default.
- W2014258144 countsByYear W20142581442015 @default.
- W2014258144 countsByYear W20142581442016 @default.
- W2014258144 countsByYear W20142581442017 @default.
- W2014258144 countsByYear W20142581442019 @default.
- W2014258144 countsByYear W20142581442022 @default.
- W2014258144 countsByYear W20142581442023 @default.
- W2014258144 crossrefType "journal-article" @default.
- W2014258144 hasAuthorship W2014258144A5015583050 @default.
- W2014258144 hasAuthorship W2014258144A5038216324 @default.
- W2014258144 hasAuthorship W2014258144A5049450190 @default.
- W2014258144 hasAuthorship W2014258144A5069406228 @default.
- W2014258144 hasConcept C126322002 @default.
- W2014258144 hasConcept C134018914 @default.
- W2014258144 hasConcept C147483822 @default.
- W2014258144 hasConcept C16613235 @default.
- W2014258144 hasConcept C185592680 @default.
- W2014258144 hasConcept C203014093 @default.
- W2014258144 hasConcept C2776946954 @default.
- W2014258144 hasConcept C2777714996 @default.
- W2014258144 hasConcept C2777961210 @default.
- W2014258144 hasConcept C2778004101 @default.
- W2014258144 hasConcept C2778815084 @default.
- W2014258144 hasConcept C2780829032 @default.
- W2014258144 hasConcept C2986274086 @default.
- W2014258144 hasConcept C31903555 @default.
- W2014258144 hasConcept C55493867 @default.
- W2014258144 hasConcept C71924100 @default.
- W2014258144 hasConceptScore W2014258144C126322002 @default.
- W2014258144 hasConceptScore W2014258144C134018914 @default.
- W2014258144 hasConceptScore W2014258144C147483822 @default.
- W2014258144 hasConceptScore W2014258144C16613235 @default.
- W2014258144 hasConceptScore W2014258144C185592680 @default.
- W2014258144 hasConceptScore W2014258144C203014093 @default.
- W2014258144 hasConceptScore W2014258144C2776946954 @default.
- W2014258144 hasConceptScore W2014258144C2777714996 @default.
- W2014258144 hasConceptScore W2014258144C2777961210 @default.
- W2014258144 hasConceptScore W2014258144C2778004101 @default.
- W2014258144 hasConceptScore W2014258144C2778815084 @default.
- W2014258144 hasConceptScore W2014258144C2780829032 @default.
- W2014258144 hasConceptScore W2014258144C2986274086 @default.
- W2014258144 hasConceptScore W2014258144C31903555 @default.
- W2014258144 hasConceptScore W2014258144C55493867 @default.
- W2014258144 hasConceptScore W2014258144C71924100 @default.
- W2014258144 hasLocation W20142581441 @default.
- W2014258144 hasLocation W20142581442 @default.
- W2014258144 hasOpenAccess W2014258144 @default.
- W2014258144 hasPrimaryLocation W20142581441 @default.
- W2014258144 hasRelatedWork W1974052876 @default.
- W2014258144 hasRelatedWork W1982704741 @default.
- W2014258144 hasRelatedWork W2014916081 @default.
- W2014258144 hasRelatedWork W2054639404 @default.
- W2014258144 hasRelatedWork W2380578532 @default.
- W2014258144 hasRelatedWork W2393814011 @default.
- W2014258144 hasRelatedWork W2416684121 @default.
- W2014258144 hasRelatedWork W2464564275 @default.
- W2014258144 hasRelatedWork W2949713967 @default.
- W2014258144 hasRelatedWork W2951287109 @default.
- W2014258144 isParatext "false" @default.
- W2014258144 isRetracted "false" @default.
- W2014258144 magId "2014258144" @default.
- W2014258144 workType "article" @default.