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• W2014259726 endingPage "89" @default.
• W2014259726 startingPage "68" @default.
• W2014259726 abstract "Although it has been suggested that the standardized Ginkgo biloba leaf extract (Egb 761) may have a beneficial effect on memory, the cellular and molecular changes that underlie this process are not yet well defined. The present study evaluated the effects of acute (one dose) or subacute treatments (one daily dose/seven days) with EGb 761 (0.5 g kg(-1) and 1.0 g kg(-1)) on rats submitted to a conditioned emotional response (CER) in comparison with positive (4 mg kg(-1) Diazepam) and negative (12%Tween 80) control groups. To this end, eighty (n=10/group) adult, male, Wistar rats (+/-250-300 g) were used in an off-baseline CER procedure. We here observed that the rats submitted to an acute and subacute EGb 761 treatments had acquisition of fear conditioning. Additionally, we investigate if the expression of genes previously associated with classical conditioning (CREB-1 and GAP-43) and new candidate genes (GFAP) are modulated following EGb 761 acute treatment. CREB-1, GAP-43 and GFAP mRNA and protein expressions were evaluated using both quantitative PCR (qPCR) and immunohistochemical analysis, respectively. We here show, for the first time, that EGb 761 modulated GAP-43, CREB-1 and GFAP expression in the prefrontal cortex, amygdala and hippocampus. We observed an underexpression of GAP-43 in all structures evaluated and over-expression of GFAP in the amygdala and hippocampus following acute G. biloba treatment when compared to control group (Tween; p<0.01). GAP-43 expression was decreased in prefrontal cortex and hippocampus in the subacute treatment with EGb 761. Subacute treatment with EGb 761 lead to a decreased CREB-1 in mPFC (p<0.001) and increased in the hippocampus to 1.0 g kg(-1)G. biloba group (p<0.001). The results obtained from immunohistochemical analysis support our aforementioned findings and revealed that the changes in expression occurred within specific regions in the areas evaluated. All together, our findings not only provide new evidence for a role of EGb 761 on memory but also identify molecular changes that underlie the fear memory consolidation." @default.
• W2014259726 created "2016-06-24" @default.
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• W2014259726 creator A5089515535 @default.
• W2014259726 date "2009-05-01" @default.
• W2014259726 modified "2023-10-01" @default.
• W2014259726 title "Neuromodulatory property of standardized extract Ginkgo biloba L. (EGb 761) on memory: Behavioral and molecular evidence" @default.
• W2014259726 cites W1542081124 @default.
• W2014259726 cites W1560820757 @default.
• W2014259726 cites W1703928766 @default.
• W2014259726 cites W1842081459 @default.
• W2014259726 cites W1909078080 @default.
• W2014259726 cites W1930989519 @default.
• W2014259726 cites W1963820036 @default.
• W2014259726 cites W1964161327 @default.
• W2014259726 cites W1967505365 @default.
• W2014259726 cites W1968605436 @default.
• W2014259726 cites W1969341826 @default.
• W2014259726 cites W1971140804 @default.
• W2014259726 cites W1973795049 @default.
• W2014259726 cites W1976131491 @default.
• W2014259726 cites W1980024704 @default.
• W2014259726 cites W1983578528 @default.
• W2014259726 cites W1984005657 @default.
• W2014259726 cites W1984506322 @default.
• W2014259726 cites W1985749282 @default.
• W2014259726 cites W1989085266 @default.
• W2014259726 cites W1989757714 @default.
• W2014259726 cites W1989983646 @default.
• W2014259726 cites W1990313772 @default.
• W2014259726 cites W1991839338 @default.
• W2014259726 cites W1993788286 @default.
• W2014259726 cites W1997167741 @default.
• W2014259726 cites W1998063324 @default.
• W2014259726 cites W1999611011 @default.
• W2014259726 cites W1999782689 @default.
• W2014259726 cites W2008037029 @default.
• W2014259726 cites W2013933538 @default.
• W2014259726 cites W2020537971 @default.
• W2014259726 cites W2021351356 @default.
• W2014259726 cites W2022767998 @default.
• W2014259726 cites W2022959246 @default.
• W2014259726 cites W2024077644 @default.
• W2014259726 cites W2028190003 @default.
• W2014259726 cites W2033746917 @default.
• W2014259726 cites W2034530607 @default.
• W2014259726 cites W2034764820 @default.
• W2014259726 cites W2034770179 @default.
• W2014259726 cites W2035079756 @default.
• W2014259726 cites W2035609793 @default.
• W2014259726 cites W2036442035 @default.
• W2014259726 cites W2036824041 @default.
• W2014259726 cites W2036872212 @default.
• W2014259726 cites W2040504736 @default.
• W2014259726 cites W2041894539 @default.
• W2014259726 cites W2042847262 @default.
• W2014259726 cites W2043348039 @default.
• W2014259726 cites W2044213359 @default.
• W2014259726 cites W2048616176 @default.
• W2014259726 cites W2049776725 @default.
• W2014259726 cites W2052922321 @default.
• W2014259726 cites W2058454186 @default.
• W2014259726 cites W2066032959 @default.
• W2014259726 cites W2067565594 @default.
• W2014259726 cites W2071056174 @default.
• W2014259726 cites W2073012254 @default.
• W2014259726 cites W2075476031 @default.
• W2014259726 cites W2075994644 @default.
• W2014259726 cites W2076345622 @default.
• W2014259726 cites W2077726006 @default.
• W2014259726 cites W2078800769 @default.
• W2014259726 cites W2083920907 @default.
• W2014259726 cites W2086986959 @default.
• W2014259726 cites W2089170472 @default.
• W2014259726 cites W2089254591 @default.
• W2014259726 cites W2092322417 @default.
• W2014259726 cites W2093805963 @default.
• W2014259726 cites W2098532348 @default.
• W2014259726 cites W2100658799 @default.
• W2014259726 cites W2101842006 @default.
• W2014259726 cites W2101995552 @default.
• W2014259726 cites W2103791867 @default.
• W2014259726 cites W2107069925 @default.
• W2014259726 cites W2113407218 @default.
• W2014259726 cites W2114008977 @default.
• W2014259726 cites W2115450455 @default.
• W2014259726 cites W2116140974 @default.
• W2014259726 cites W2118977349 @default.
• W2014259726 cites W2123597506 @default.
• W2014259726 cites W2127186613 @default.
• W2014259726 cites W2133083344 @default.
• W2014259726 cites W2133850147 @default.
• W2014259726 cites W2136827845 @default.

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