FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014263707> ?p ?o ?g. }

• W2014263707 endingPage "612" @default.
• W2014263707 startingPage "606" @default.
• W2014263707 abstract "Cells undergo apoptosis in stressed status such as in intracellular calcium overload or extracellular calcium/magnesium deficiency. The mechanisms of how deficiency of the divalent metal ions induces apoptosis remain to be defined. Scavenger receptor BI (SR-BI) is a high density lipoprotein (HDL) receptor. Recent studies demonstrated that SR-BI is a stress response molecule which induces apoptosis upon serum deprivation. In this study, we assessed our hypothesis that the deficiency of calcium/magnesium induces apoptosis via SR-BI apoptotic pathway.We employed CHO cell lines expressing vector and SR-BI to test the effect of SR-BI on apoptosis induced by deficiency of calcium, magnesium and zinc in culture medium. The regain of different metal ions in deficient medium was also performed, respectively. Cell death was detected by morphological changes and quantified by LDH cytotoxicity assay. Apoptosis was also assessed by DNA ladder assay and DNA condensation assay. The SR-BIC323G mutant cells which lack the apoptotic activity of SR-BI were employed to verify the SR-BI-dependent effect on calcium/magnesium induced apoptosis.The deficiency of calcium/magnesium induced cell apoptosis in CHO-SR-BI cells, but not in CHO-vector cells. Moreover, no apoptotic cell death was observed in SR-BIC323G mutant cells, indicating that the deficiency of divalent metal ions induces apoptosis in a SR-BI-dependent manner. Furthermore, the restoration of calcium or magnesium, but not zinc, protected CHO-SR-BI cells from apoptotic cell death, in a dose-dependent fashion.These findings extend our understanding about how calcium and magnesium deficiency induces apoptosis." @default.
• W2014263707 created "2016-06-24" @default.
• W2014263707 creator A5031953660 @default.
• W2014263707 creator A5042284627 @default.
• W2014263707 creator A5045921288 @default.
• W2014263707 creator A5065351411 @default.
• W2014263707 date "2011-03-01" @default.
• W2014263707 modified "2023-09-23" @default.
• W2014263707 title "Deficiency of calcium and magnesium induces apoptosis via scavenger receptor BI" @default.
• W2014263707 cites W102942757 @default.
• W2014263707 cites W1745634660 @default.
• W2014263707 cites W1935200679 @default.
• W2014263707 cites W1967463041 @default.
• W2014263707 cites W1978563221 @default.
• W2014263707 cites W1979696861 @default.
• W2014263707 cites W1985170971 @default.
• W2014263707 cites W1995638940 @default.
• W2014263707 cites W1995952106 @default.
• W2014263707 cites W2002569533 @default.
• W2014263707 cites W2009205954 @default.
• W2014263707 cites W2012115247 @default.
• W2014263707 cites W2043057554 @default.
• W2014263707 cites W2047057336 @default.
• W2014263707 cites W2052067930 @default.
• W2014263707 cites W2052083649 @default.
• W2014263707 cites W2060893933 @default.
• W2014263707 cites W2062297873 @default.
• W2014263707 cites W2066736055 @default.
• W2014263707 cites W2073308465 @default.
• W2014263707 cites W2079011786 @default.
• W2014263707 cites W2085547046 @default.
• W2014263707 cites W2088154205 @default.
• W2014263707 cites W2088793021 @default.
• W2014263707 cites W2090951546 @default.
• W2014263707 cites W2091354907 @default.
• W2014263707 cites W2097950610 @default.
• W2014263707 cites W2101535275 @default.
• W2014263707 cites W2114269768 @default.
• W2014263707 cites W2137121081 @default.
• W2014263707 cites W2138298723 @default.
• W2014263707 cites W2145664512 @default.
• W2014263707 cites W2153696719 @default.
• W2014263707 cites W2156818917 @default.
• W2014263707 cites W2158009878 @default.
• W2014263707 cites W2160276559 @default.
• W2014263707 cites W2169970337 @default.
• W2014263707 cites W2171700147 @default.
• W2014263707 cites W2335055505 @default.
• W2014263707 cites W2409766273 @default.
• W2014263707 cites W4252866398 @default.
• W2014263707 cites W2046732645 @default.
• W2014263707 doi "https://doi.org/10.1016/j.lfs.2011.01.020" @default.
• W2014263707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3061308" @default.
• W2014263707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21291896" @default.
• W2014263707 hasPublicationYear "2011" @default.
• W2014263707 type Work @default.
• W2014263707 sameAs 2014263707 @default.
• W2014263707 citedByCount "20" @default.
• W2014263707 countsByYear W20142637072014 @default.
• W2014263707 countsByYear W20142637072017 @default.
• W2014263707 countsByYear W20142637072018 @default.
• W2014263707 countsByYear W20142637072019 @default.
• W2014263707 countsByYear W20142637072020 @default.
• W2014263707 countsByYear W20142637072021 @default.
• W2014263707 countsByYear W20142637072022 @default.
• W2014263707 countsByYear W20142637072023 @default.
• W2014263707 crossrefType "journal-article" @default.
• W2014263707 hasAuthorship W2014263707A5031953660 @default.
• W2014263707 hasAuthorship W2014263707A5042284627 @default.
• W2014263707 hasAuthorship W2014263707A5045921288 @default.
• W2014263707 hasAuthorship W2014263707A5065351411 @default.
• W2014263707 hasBestOaLocation W20142637072 @default.
• W2014263707 hasConcept C153911025 @default.
• W2014263707 hasConcept C178790620 @default.
• W2014263707 hasConcept C181080969 @default.
• W2014263707 hasConcept C185592680 @default.
• W2014263707 hasConcept C190283241 @default.
• W2014263707 hasConcept C31573885 @default.
• W2014263707 hasConcept C519063684 @default.
• W2014263707 hasConcept C55493867 @default.
• W2014263707 hasConcept C86803240 @default.
• W2014263707 hasConcept C95444343 @default.
• W2014263707 hasConceptScore W2014263707C153911025 @default.
• W2014263707 hasConceptScore W2014263707C178790620 @default.
• W2014263707 hasConceptScore W2014263707C181080969 @default.
• W2014263707 hasConceptScore W2014263707C185592680 @default.
• W2014263707 hasConceptScore W2014263707C190283241 @default.
• W2014263707 hasConceptScore W2014263707C31573885 @default.
• W2014263707 hasConceptScore W2014263707C519063684 @default.
• W2014263707 hasConceptScore W2014263707C55493867 @default.
• W2014263707 hasConceptScore W2014263707C86803240 @default.
• W2014263707 hasConceptScore W2014263707C95444343 @default.
• W2014263707 hasIssue "13-14" @default.
• W2014263707 hasLocation W20142637071 @default.
• W2014263707 hasLocation W20142637072 @default.
• W2014263707 hasLocation W20142637073 @default.
• W2014263707 hasLocation W20142637074 @default.
• W2014263707 hasOpenAccess W2014263707 @default.

• next