Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014268697> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2014268697 abstract "The G protein-coupled receptor kinase 2 (GRK2) phosphorylates and shuts down signaling from 7-transmembrane receptors (7TMs). Although, receptor activity controls GRK2 expression levels, the underlying molecular mechanisms are poorly understood. We have previously shown that extracellular signal-regulated kinase (ERK1/2) activation increases GRK2 expression [J. Theilade, J. Lerche Hansen, S. Haunso, S.P. Sheikh, Extracellular signal-regulated kinases control expression of G protein-coupled receptor kinase 2 (GRK2), FEBS Lett. 518 (2002) 195-199]. In the present study, we found that ERK1/2 regulates GRK2 degradation rather than synthesis. ERK1/2 blockade using PD98059 decreased GRK2 cellular levels to 0.25-fold of control in Cos7 cells. This effect was due to enhanced degradation of the GRK2 protein, since proteasome blockade prevented down-regulation of GRK2 protein levels in the presence of PD98059. Further, ERK blockade had no effect on GRK2 synthesis as probed using a reporter construct carrying the GRK2 promoter upstream of the luciferase gene. We predict ERK1/2 mediated GRK2 protection could be a general phenomenon as proteasome inhibition increased GRK2 expression in two other cell lines, HEK293 and NIH3T3." @default.
- W2014268697 created "2016-06-24" @default.
- W2014268697 creator A5005600302 @default.
- W2014268697 creator A5036231929 @default.
- W2014268697 creator A5046533529 @default.
- W2014268697 creator A5062098369 @default.
- W2014268697 date "2005-05-01" @default.
- W2014268697 modified "2023-09-25" @default.
- W2014268697 title "MAP kinase protects G protein-coupled receptor kinase 2 from proteasomal degradation" @default.
- W2014268697 cites W1245933497 @default.
- W2014268697 cites W1498838285 @default.
- W2014268697 cites W1549603309 @default.
- W2014268697 cites W1602242875 @default.
- W2014268697 cites W1979197099 @default.
- W2014268697 cites W1999530386 @default.
- W2014268697 cites W2000336003 @default.
- W2014268697 cites W2005026826 @default.
- W2014268697 cites W2008744347 @default.
- W2014268697 cites W2016526612 @default.
- W2014268697 cites W2027217537 @default.
- W2014268697 cites W2031108838 @default.
- W2014268697 cites W2032848541 @default.
- W2014268697 cites W2033626933 @default.
- W2014268697 cites W2035936653 @default.
- W2014268697 cites W2040372727 @default.
- W2014268697 cites W2050252881 @default.
- W2014268697 cites W2055375040 @default.
- W2014268697 cites W2060207881 @default.
- W2014268697 cites W2078748771 @default.
- W2014268697 cites W2083833577 @default.
- W2014268697 cites W2101007077 @default.
- W2014268697 cites W2117255892 @default.
- W2014268697 cites W2123271369 @default.
- W2014268697 cites W2149239576 @default.
- W2014268697 cites W2152665674 @default.
- W2014268697 cites W2155432244 @default.
- W2014268697 cites W2419438832 @default.
- W2014268697 cites W2614496215 @default.
- W2014268697 doi "https://doi.org/10.1016/j.bbrc.2005.03.044" @default.
- W2014268697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15809051" @default.
- W2014268697 hasPublicationYear "2005" @default.
- W2014268697 type Work @default.
- W2014268697 sameAs 2014268697 @default.
- W2014268697 citedByCount "7" @default.
- W2014268697 countsByYear W20142686972012 @default.
- W2014268697 countsByYear W20142686972016 @default.
- W2014268697 crossrefType "journal-article" @default.
- W2014268697 hasAuthorship W2014268697A5005600302 @default.
- W2014268697 hasAuthorship W2014268697A5036231929 @default.
- W2014268697 hasAuthorship W2014268697A5046533529 @default.
- W2014268697 hasAuthorship W2014268697A5062098369 @default.
- W2014268697 hasConcept C104317684 @default.
- W2014268697 hasConcept C135285700 @default.
- W2014268697 hasConcept C143065580 @default.
- W2014268697 hasConcept C153911025 @default.
- W2014268697 hasConcept C170493617 @default.
- W2014268697 hasConcept C184235292 @default.
- W2014268697 hasConcept C185592680 @default.
- W2014268697 hasConcept C32619005 @default.
- W2014268697 hasConcept C33235085 @default.
- W2014268697 hasConcept C55493867 @default.
- W2014268697 hasConcept C57074206 @default.
- W2014268697 hasConcept C62478195 @default.
- W2014268697 hasConcept C78976303 @default.
- W2014268697 hasConcept C86803240 @default.
- W2014268697 hasConcept C95444343 @default.
- W2014268697 hasConceptScore W2014268697C104317684 @default.
- W2014268697 hasConceptScore W2014268697C135285700 @default.
- W2014268697 hasConceptScore W2014268697C143065580 @default.
- W2014268697 hasConceptScore W2014268697C153911025 @default.
- W2014268697 hasConceptScore W2014268697C170493617 @default.
- W2014268697 hasConceptScore W2014268697C184235292 @default.
- W2014268697 hasConceptScore W2014268697C185592680 @default.
- W2014268697 hasConceptScore W2014268697C32619005 @default.
- W2014268697 hasConceptScore W2014268697C33235085 @default.
- W2014268697 hasConceptScore W2014268697C55493867 @default.
- W2014268697 hasConceptScore W2014268697C57074206 @default.
- W2014268697 hasConceptScore W2014268697C62478195 @default.
- W2014268697 hasConceptScore W2014268697C78976303 @default.
- W2014268697 hasConceptScore W2014268697C86803240 @default.
- W2014268697 hasConceptScore W2014268697C95444343 @default.
- W2014268697 hasLocation W20142686971 @default.
- W2014268697 hasLocation W20142686972 @default.
- W2014268697 hasOpenAccess W2014268697 @default.
- W2014268697 hasPrimaryLocation W20142686971 @default.
- W2014268697 hasRelatedWork W1983732891 @default.
- W2014268697 hasRelatedWork W2014268697 @default.
- W2014268697 hasRelatedWork W2033611080 @default.
- W2014268697 hasRelatedWork W2078026261 @default.
- W2014268697 hasRelatedWork W2081351136 @default.
- W2014268697 hasRelatedWork W2115390876 @default.
- W2014268697 hasRelatedWork W2117255892 @default.
- W2014268697 hasRelatedWork W2384817912 @default.
- W2014268697 hasRelatedWork W2419396930 @default.
- W2014268697 hasRelatedWork W3035328115 @default.
- W2014268697 isParatext "false" @default.
- W2014268697 isRetracted "false" @default.
- W2014268697 magId "2014268697" @default.
- W2014268697 workType "article" @default.