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- W2014269458 abstract "Background and Purpose: Treatment of chronic insomnia with nightly hypnotics is efficacious, but discontinuation is recommended after 1 month, less than the average disease duration. This study was undertaken to determine the efficacy of intermittent administration. Patients and Methods: A double-blind study was carried out on 8 patients (age, 32.8 ± 9 years; 3 men) with primary sleep maintenance insomnia longer than 1 month. Polysomnography of conventional sleep parameters, cyclic alternating patterns (CAPs), and arousals was performed. Perception of sleep quality was assessed on a visual analog scale. After an adaptation night, baselines were recorded followed by 6 consecutive nights of alternating treatment with zolpidem (10 mg) or placebo. Results: Significant improvements on baseline values (P < 0.0001) were observed on all 3 active treatment nights for total sleep time, sleep efficiency, CAP time, CAP rate, subtype A2, arousals, and arousal index. Deep non-rapid eye movement sleep increased with the second and third doses of active treatment (P < 0.0001). Rapid eye movement sleep increased during the last 3 polysomnographic recordings (P < 0.014). Sleep quality (visual analog scale) improved on all nights after the initial dose of active treatment (P < 0.0001). There was no evidence of rebound insomnia with placebo. Conclusions: Intermittent treatment with zolpidem in primary insomnia patients improves CAP parameters and arousals, as well as sleep duration and quality, in the absence of rebound insomnia." @default.
- W2014269458 created "2016-06-24" @default.
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- W2014269458 date "2008-01-01" @default.
- W2014269458 modified "2023-09-27" @default.
- W2014269458 title "Polysomnographic Study of Intermittent Zolpidem Treatment in Primary Sleep Maintenance Insomnia" @default.
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- W2014269458 doi "https://doi.org/10.1097/wnf.0b013e3180674e0e" @default.
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