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- W2014271878 endingPage "343" @default.
- W2014271878 startingPage "331" @default.
- W2014271878 abstract "GABAA receptors mediate most inhibitory synaptic transmission, and their assembly and trafficking in neurons is tightly regulated. Moss and colleagues review our current knowledge about the molecular mechanisms that regulate GABAAreceptor trafficking and their contribution to neuronal function. GABA (γ-aminobutyric acid) type A receptors (GABAARs) mediate most fast synaptic inhibition in the mammalian brain, controlling activity at both the network and the cellular levels. The diverse functions of GABA in the CNS are matched not just by the heterogeneity of GABAARs, but also by the complex trafficking mechanisms and protein–protein interactions that generate and maintain an appropriate receptor cell-surface localization. In this Review, we discuss recent progress in our understanding of the dynamic regulation of GABAAR composition, trafficking to and from the neuronal surface, and lateral movement of receptors between synaptic and extrasynaptic locations. Finally, we highlight a number of neurological disorders, including epilepsy and schizophrenia, in which alterations in GABAAR trafficking occur." @default.
- W2014271878 created "2016-06-24" @default.
- W2014271878 creator A5001189787 @default.
- W2014271878 creator A5020338130 @default.
- W2014271878 creator A5080984230 @default.
- W2014271878 date "2008-05-01" @default.
- W2014271878 modified "2023-10-14" @default.
- W2014271878 title "GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition" @default.
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