FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014272960> ?p ?o ?g. }

• W2014272960 endingPage "463" @default.
• W2014272960 startingPage "457" @default.
• W2014272960 abstract "Abstract: A rat neuroma cell line (B103 4C), deficient of hypoxanthine-guanine phosphoribosyltransferase (HGPRT), was utilized as a model tissue in search for the biochemical basis of the Lesch-Nyhan syndrome (LNS). The HGPRT-deficient neurons exhibited the following properties: an almost complete absence of uptake of guanine and of hypoxanthine into intact cell nucleotides (0.92% and 0.69% of normal, respectively); a significant increase in the availability of 5′-phosphoribosyl-1-pyrophosphate; a three- to fourfold acceleration of the rate of de novo nucleotide synthesis; a normal excretion of xanthine, but 15-fold increase in the excretion of hypoxanthine into the culture media; a normal cellular purine nucleotide content, including the absence of 5-amino-4-imidazole carboxamide nucleotides (Z-nucleotides), but enhanced turnover of adenine nucleotides (loss of 86% of the radioactivity of the prelabeled pool in 24 h, in comparison to 73% in the normal line), and an elevated UTP content. The results suggest that, under physiological conditions, guanine salvage does not occur in the normal neurons, but that hypoxanthine salvage is of great importance in the homeostasis of the adenine nucleotide pool. The finding of the normal profile of purine nucleotides in the HGPRT-deficient neurons indicates that the lack of hypoxanthine salvage is adequately compensated by the enhanced de novo nucleotide synthesis. These results did not furnish evidence in support of the possibility that GTP or ATP depletion, or Z-nucleotide accumulation, occurs in HGPRT-deficient neurons and that these are etiological factors causing the neurological abnormalities in LNS. On the other hand, the results point to the possibility that elevated hypoxanthine concentration in the brain may have an etiological role in the pathogenesis of LNS." @default.
• W2014272960 created "2016-06-24" @default.
• W2014272960 creator A5046513816 @default.
• W2014272960 creator A5069750041 @default.
• W2014272960 creator A5080723862 @default.
• W2014272960 creator A5086787074 @default.
• W2014272960 creator A5089255624 @default.
• W2014272960 date "2006-10-05" @default.
• W2014272960 modified "2023-10-18" @default.
• W2014272960 title "Characterization of the Alterations in Purine Nucleotide Metabolism in Hypoxanthine-Guardne Phosphoribosyltransferase-Deficient Rat Neuroma Cell Line" @default.
• W2014272960 cites W119965119 @default.
• W2014272960 cites W1539181208 @default.
• W2014272960 cites W15437154 @default.
• W2014272960 cites W1775749144 @default.
• W2014272960 cites W1978911529 @default.
• W2014272960 cites W1988625599 @default.
• W2014272960 cites W1994231412 @default.
• W2014272960 cites W1994932207 @default.
• W2014272960 cites W2005364742 @default.
• W2014272960 cites W2007582128 @default.
• W2014272960 cites W2016650450 @default.
• W2014272960 cites W2024683111 @default.
• W2014272960 cites W2025580330 @default.
• W2014272960 cites W2031258323 @default.
• W2014272960 cites W2037845589 @default.
• W2014272960 cites W2038391658 @default.
• W2014272960 cites W2039584715 @default.
• W2014272960 cites W2046685443 @default.
• W2014272960 cites W2064479755 @default.
• W2014272960 cites W2065327100 @default.
• W2014272960 cites W2075523045 @default.
• W2014272960 cites W2080561657 @default.
• W2014272960 cites W2080915025 @default.
• W2014272960 cites W2084300401 @default.
• W2014272960 cites W2089373404 @default.
• W2014272960 cites W2092342343 @default.
• W2014272960 cites W2107741180 @default.
• W2014272960 cites W2120613619 @default.
• W2014272960 cites W2125655791 @default.
• W2014272960 cites W2173348675 @default.
• W2014272960 cites W4240609217 @default.
• W2014272960 cites W4249182791 @default.
• W2014272960 cites W57520250 @default.
• W2014272960 doi "https://doi.org/10.1111/j.1471-4159.1993.tb02146.x" @default.
• W2014272960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8336135" @default.
• W2014272960 hasPublicationYear "2006" @default.
• W2014272960 type Work @default.
• W2014272960 sameAs 2014272960 @default.
• W2014272960 citedByCount "36" @default.
• W2014272960 countsByYear W20142729602012 @default.
• W2014272960 countsByYear W20142729602013 @default.
• W2014272960 countsByYear W20142729602015 @default.
• W2014272960 countsByYear W20142729602016 @default.
• W2014272960 countsByYear W20142729602018 @default.
• W2014272960 countsByYear W20142729602020 @default.
• W2014272960 countsByYear W20142729602021 @default.
• W2014272960 countsByYear W20142729602023 @default.
• W2014272960 crossrefType "journal-article" @default.
• W2014272960 hasAuthorship W2014272960A5046513816 @default.
• W2014272960 hasAuthorship W2014272960A5069750041 @default.
• W2014272960 hasAuthorship W2014272960A5080723862 @default.
• W2014272960 hasAuthorship W2014272960A5086787074 @default.
• W2014272960 hasAuthorship W2014272960A5089255624 @default.
• W2014272960 hasConcept C104317684 @default.
• W2014272960 hasConcept C143065580 @default.
• W2014272960 hasConcept C181199279 @default.
• W2014272960 hasConcept C185592680 @default.
• W2014272960 hasConcept C2776476023 @default.
• W2014272960 hasConcept C2777766392 @default.
• W2014272960 hasConcept C2777991568 @default.
• W2014272960 hasConcept C2778301229 @default.
• W2014272960 hasConcept C2779470414 @default.
• W2014272960 hasConcept C2781116151 @default.
• W2014272960 hasConcept C2909697302 @default.
• W2014272960 hasConcept C2994266630 @default.
• W2014272960 hasConcept C512185932 @default.
• W2014272960 hasConcept C55493867 @default.
• W2014272960 hasConcept C78179603 @default.
• W2014272960 hasConcept C86803240 @default.
• W2014272960 hasConceptScore W2014272960C104317684 @default.
• W2014272960 hasConceptScore W2014272960C143065580 @default.
• W2014272960 hasConceptScore W2014272960C181199279 @default.
• W2014272960 hasConceptScore W2014272960C185592680 @default.
• W2014272960 hasConceptScore W2014272960C2776476023 @default.
• W2014272960 hasConceptScore W2014272960C2777766392 @default.
• W2014272960 hasConceptScore W2014272960C2777991568 @default.
• W2014272960 hasConceptScore W2014272960C2778301229 @default.
• W2014272960 hasConceptScore W2014272960C2779470414 @default.
• W2014272960 hasConceptScore W2014272960C2781116151 @default.
• W2014272960 hasConceptScore W2014272960C2909697302 @default.
• W2014272960 hasConceptScore W2014272960C2994266630 @default.
• W2014272960 hasConceptScore W2014272960C512185932 @default.
• W2014272960 hasConceptScore W2014272960C55493867 @default.
• W2014272960 hasConceptScore W2014272960C78179603 @default.
• W2014272960 hasConceptScore W2014272960C86803240 @default.
• W2014272960 hasIssue "2" @default.
• W2014272960 hasLocation W20142729601 @default.
• W2014272960 hasLocation W20142729602 @default.

• next