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• W2014273057 startingPage "e29805" @default.
• W2014273057 abstract "Human CD4+ T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound self-peptides presented by CD4+ T cells in order to compare the T cell-derived peptide repertoire to sequences derived from genetically identical B cells. We identified several novel epitopes derived from the T cell-specific proteome, including fragments of CD4 and IL-2. While these data confirm that T cells can present peptides derived from the T-cell specific proteome, the vast majority of peptides sequenced after elution from MHC were derived from the common proteome. From this pool, we identified several identical peptide epitopes in the T and B cell repertoire derived from common endogenous proteins as well as novel endogenous epitopes with promiscuous binding. These findings indicate that the endogenous HLA-DR-bound peptide repertoire, regardless of APC type and across MHC isotype, is largely derived from the same pool of self-protein." @default.
• W2014273057 created "2016-06-24" @default.
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• W2014273057 creator A5081514135 @default.
• W2014273057 date "2012-01-27" @default.
• W2014273057 modified "2023-09-27" @default.
• W2014273057 title "Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes" @default.
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• W2014273057 doi "https://doi.org/10.1371/journal.pone.0029805" @default.
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