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- W2014276098 abstract "1 The roles of excitatory and inhibitory intrinsic motor nerves on contractions reflexly evoked by wall distension were investigated in the isolated sphincter of Oddi of the guinea-pig (SO-GP). 2 Distension of the terminal bile duct for 30–60 s time periods increased the frequency of contractions from about 2 to 12 min−1 (n=16). 3 Hexamethonium (HEX; 300 μm) largely prevented the distension-evoked increase in contraction frequency (4.5 min−1, n=8) as did atropine (ATR; 1 μm) (0.8 min−1, n=6), while tetrodotoxin (TTX; 1 μm) blocked the contractions triggered during distension. 4 L-nitroarginine (L-NA; 100 μm) significantly increased the frequency of contractions during and in the absence distension while apamin (APAM; 0.5 μm) significantly increased their frequency and doubled their mean amplitude during distension. 5 These results suggest that distension activates excitatory cholinergic motor nerves to increase the frequency of contractions in the SO-GP. These actions are modulated by the concomitant activation of intrinsic nitrergic and non-nitrergic inhibitory motor nerves." @default.
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- W2014276098 title "Functional innervation of the biliary sphincter of the guinea-pig revealed by anti-autonomic drugs" @default.
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- W2014276098 doi "https://doi.org/10.1046/j.1365-2680.2000.00182.x" @default.
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