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- W2014276467 abstract "Abstract λc17 is a mutant of λ originally recognized by Pereira da Silva because of its nearly clear plaque morphology on a sensitive host and its ability to give virulence when combined in cis with certain cI mutations. Experiments are presented which show that c17 confers on the chromosome which carries it two unique and distinct properties: constitutive function of genes O and P and loss of normal sensitivity to replication inhibition. These properties lead to constitutive replication of λc17 DNA in the immune host and to host killing, even though λc17 does not lyse an immune host and release progeny phage unless it also carries a cI mutation. A model is presented to explain λc17cI virulence that proposes that those λc17 genes which are subject to cI repression in the immune host can be derepressed if phage replication produces too many phage chromosomes for the cI repressor to control. It is proposed that this derepression can occur only if the replicating element is unable to augment the level of free repressor produced by the prophage, i.e., if it contains a cI mutation." @default.
- W2014276467 created "2016-06-24" @default.
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- W2014276467 date "1968-04-01" @default.
- W2014276467 modified "2023-09-26" @default.
- W2014276467 title "Constitutive λ DNA replication by λc17, a regulatory mutant related to virulence" @default.
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- W2014276467 doi "https://doi.org/10.1016/0042-6822(68)90099-8" @default.
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