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- W2014280014 abstract "Three water soluble and 6 bifunctional newly synthesized analogs of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) were screened for anticancer activity against subcutaneously and intracerebrally inoculated Walker carcinosarcoma 256 and 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary cancer of the rat. The water soluble 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea showed a higher activity than BCNU in s.c. inoculated Walker carcinosarcoma 256 in several experiments. Treatment of i.c. inoculated Walker carcinosarcoma 256 with the bifunctional analogs and 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea resulted in a marked increase in lifespan over untreated rats. However, statistically no differences were found in comparison to the treatment with BCNU. Against the DMBA induced mammary cancer of the rat, only 2 new analogs were examined; they produced a smaller tumor weight inhibition than BCNU. Further investigations are under work to examine the activity of the new compounds against chemically induced brain tumors." @default.
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- W2014280014 date "1977-09-01" @default.
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- W2014280014 title "Water soluble derivatives and bifunctional analogs of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)" @default.
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- W2014280014 doi "https://doi.org/10.1016/0014-2964(77)90169-4" @default.
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