FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014281832> ?p ?o ?g. }

• W2014281832 endingPage "1155" @default.
• W2014281832 startingPage "1152" @default.
• W2014281832 abstract "The SMAD-2 gene, which is located at 18q21, has been identified as a candidate tumour-suppressor gene from work on colorectal cancers. The aim of the present study was to determine the clinical alterations and the significance of its mutations in a series of colorectal cancers previously examined for SMAD-4/DPC-4 gene. Mutation analyses of the SMAD-2 gene were carried out on cDNA samples from 36 primary colorectal cancer specimens using a combination of the polymerase chain reaction (PCR), single-strand conformation polymorphism (SSCP) and DNA sequencing. Only one missense mutation (2.8%), producing an amino acid substitution in the highly conserved region, and two homozygous deletions (5.5%) of the total coding region of the SMAD-2 gene were detected in the 36 cancers. The SMAD-2 gene may play a role as a candidate tumour-suppressor gene in a small fraction of colorectal cancers. However, allelic loss at 18q21 is very often seen in this type of tumour. Even in combination with changes in SMAD-4, the observed frequency was not sufficient to account for all 18q21 deletions in colorectal cancers. Thus, another tumour-suppressor gene, such as DCC, discovered as the first tumour-suppressor candidate in the region may also exist in this chromosome region." @default.
• W2014281832 created "2016-06-24" @default.
• W2014281832 creator A5009996620 @default.
• W2014281832 creator A5016739056 @default.
• W2014281832 creator A5023964799 @default.
• W2014281832 creator A5031173836 @default.
• W2014281832 creator A5034371838 @default.
• W2014281832 creator A5034741577 @default.
• W2014281832 creator A5067561532 @default.
• W2014281832 creator A5068980446 @default.
• W2014281832 creator A5072329283 @default.
• W2014281832 date "1998-11-01" @default.
• W2014281832 modified "2023-10-18" @default.
• W2014281832 title "Somatic alterations of the SMAD-2 gene in human colorectal cancers" @default.
• W2014281832 cites W1491299748 @default.
• W2014281832 cites W1937967370 @default.
• W2014281832 cites W1980847511 @default.
• W2014281832 cites W1985793111 @default.
• W2014281832 cites W2037268137 @default.
• W2014281832 cites W2058907961 @default.
• W2014281832 cites W2068132469 @default.
• W2014281832 cites W2080546144 @default.
• W2014281832 cites W2082466352 @default.
• W2014281832 cites W2091723114 @default.
• W2014281832 cites W2093417867 @default.
• W2014281832 cites W2096590212 @default.
• W2014281832 cites W2100522747 @default.
• W2014281832 cites W2147039086 @default.
• W2014281832 cites W2170251559 @default.
• W2014281832 cites W2402029145 @default.
• W2014281832 cites W308712928 @default.
• W2014281832 cites W4252562012 @default.
• W2014281832 doi "https://doi.org/10.1038/bjc.1998.645" @default.
• W2014281832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2063002" @default.
• W2014281832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9820171" @default.
• W2014281832 hasPublicationYear "1998" @default.
• W2014281832 type Work @default.
• W2014281832 sameAs 2014281832 @default.
• W2014281832 citedByCount "79" @default.
• W2014281832 countsByYear W20142818322012 @default.
• W2014281832 countsByYear W20142818322013 @default.
• W2014281832 countsByYear W20142818322015 @default.
• W2014281832 countsByYear W20142818322016 @default.
• W2014281832 countsByYear W20142818322017 @default.
• W2014281832 countsByYear W20142818322018 @default.
• W2014281832 countsByYear W20142818322020 @default.
• W2014281832 countsByYear W20142818322021 @default.
• W2014281832 countsByYear W20142818322022 @default.
• W2014281832 crossrefType "journal-article" @default.
• W2014281832 hasAuthorship W2014281832A5009996620 @default.
• W2014281832 hasAuthorship W2014281832A5016739056 @default.
• W2014281832 hasAuthorship W2014281832A5023964799 @default.
• W2014281832 hasAuthorship W2014281832A5031173836 @default.
• W2014281832 hasAuthorship W2014281832A5034371838 @default.
• W2014281832 hasAuthorship W2014281832A5034741577 @default.
• W2014281832 hasAuthorship W2014281832A5067561532 @default.
• W2014281832 hasAuthorship W2014281832A5068980446 @default.
• W2014281832 hasAuthorship W2014281832A5072329283 @default.
• W2014281832 hasBestOaLocation W20142818322 @default.
• W2014281832 hasConcept C104317684 @default.
• W2014281832 hasConcept C121608353 @default.
• W2014281832 hasConcept C153911025 @default.
• W2014281832 hasConcept C29906990 @default.
• W2014281832 hasConcept C2994225774 @default.
• W2014281832 hasConcept C501734568 @default.
• W2014281832 hasConcept C502942594 @default.
• W2014281832 hasConcept C526805850 @default.
• W2014281832 hasConcept C54355233 @default.
• W2014281832 hasConcept C75563809 @default.
• W2014281832 hasConcept C86803240 @default.
• W2014281832 hasConceptScore W2014281832C104317684 @default.
• W2014281832 hasConceptScore W2014281832C121608353 @default.
• W2014281832 hasConceptScore W2014281832C153911025 @default.
• W2014281832 hasConceptScore W2014281832C29906990 @default.
• W2014281832 hasConceptScore W2014281832C2994225774 @default.
• W2014281832 hasConceptScore W2014281832C501734568 @default.
• W2014281832 hasConceptScore W2014281832C502942594 @default.
• W2014281832 hasConceptScore W2014281832C526805850 @default.
• W2014281832 hasConceptScore W2014281832C54355233 @default.
• W2014281832 hasConceptScore W2014281832C75563809 @default.
• W2014281832 hasConceptScore W2014281832C86803240 @default.
• W2014281832 hasIssue "9" @default.
• W2014281832 hasLocation W20142818321 @default.
• W2014281832 hasLocation W20142818322 @default.
• W2014281832 hasLocation W20142818323 @default.
• W2014281832 hasLocation W20142818324 @default.
• W2014281832 hasOpenAccess W2014281832 @default.
• W2014281832 hasPrimaryLocation W20142818321 @default.
• W2014281832 hasRelatedWork W1967434184 @default.
• W2014281832 hasRelatedWork W1971499146 @default.
• W2014281832 hasRelatedWork W1979176079 @default.
• W2014281832 hasRelatedWork W1983364384 @default.
• W2014281832 hasRelatedWork W2079236421 @default.
• W2014281832 hasRelatedWork W2162724184 @default.
• W2014281832 hasRelatedWork W2168024132 @default.
• W2014281832 hasRelatedWork W2329070144 @default.
• W2014281832 hasRelatedWork W2931132270 @default.
• W2014281832 hasRelatedWork W3034319493 @default.

• next