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• W2014283432 startingPage "1581" @default.
• W2014283432 abstract "To identify genes affecting bone strength, we studied how genetic variants regulate components of a phenotypic covariation network that was previously shown to accurately characterize the compensatory trait interactions involved in functional adaptation during growth. Quantitative trait loci (QTLs) regulating femoral robustness, morphologic compensation, and mineralization (tissue quality) were mapped at three ages during growth using AXB/BXA Recombinant Inbred (RI) mouse strains and adult B6-i(A) Chromosome Substitution Strains (CSS). QTLs for robustness were identified on chromosomes 8, 12, 18, and 19 and confirmed at all three ages, indicating that genetic variants established robustness postnatally without further modification. A QTL for morphologic compensation, which was measured as the relationship between cortical area and body weight, was identified on chromosome 8. This QTL limited the amount of bone formed during growth and thus acted as a setpoint for diaphyseal bone mass. Additional QTLs were identified from the CSS analysis. QTLs for robustness and morphologic compensation regulated bone structure independently (ie, in a nonpleiotropic manner), indicating that each trait may be targeted separately to individualize treatments aiming to improve strength. Multiple regression analyses showed that variation in morphologic compensation and tissue quality, not bone size, determined femoral strength relative to body weight. Thus an individual inheriting slender bones will not necessarily inherit weak bones unless the individual also inherits a gene that impairs compensation. This systems genetic analysis showed that genetically determined phenotype covariation networks control bone strength, suggesting that incorporating functional adaptation into genetic analyses will advance our understanding of the genetic basis of bone strength." @default.
• W2014283432 created "2016-06-24" @default.
• W2014283432 creator A5022511735 @default.
• W2014283432 creator A5049733060 @default.
• W2014283432 creator A5091606904 @default.
• W2014283432 date "2010-06-30" @default.
• W2014283432 modified "2023-10-10" @default.
• W2014283432 title "Genetically determined phenotype covariation networks control bone strength" @default.
• W2014283432 cites W1554180547 @default.
• W2014283432 cites W1807892535 @default.
• W2014283432 cites W1966610596 @default.
• W2014283432 cites W1968728164 @default.
• W2014283432 cites W1971657384 @default.
• W2014283432 cites W1977379015 @default.
• W2014283432 cites W1978064775 @default.
• W2014283432 cites W1978763998 @default.
• W2014283432 cites W1979105043 @default.
• W2014283432 cites W1986991051 @default.
• W2014283432 cites W1989038652 @default.
• W2014283432 cites W1992587657 @default.
• W2014283432 cites W1994597310 @default.
• W2014283432 cites W1996038020 @default.
• W2014283432 cites W1996131009 @default.
• W2014283432 cites W1998726695 @default.
• W2014283432 cites W2001708988 @default.
• W2014283432 cites W2003785361 @default.
• W2014283432 cites W2003998239 @default.
• W2014283432 cites W2012975927 @default.
• W2014283432 cites W2014175842 @default.
• W2014283432 cites W2017966093 @default.
• W2014283432 cites W2019993605 @default.
• W2014283432 cites W2020476422 @default.
• W2014283432 cites W2021843442 @default.
• W2014283432 cites W2023080627 @default.
• W2014283432 cites W2025913781 @default.
• W2014283432 cites W2031524973 @default.
• W2014283432 cites W2034608799 @default.
• W2014283432 cites W2037011614 @default.
• W2014283432 cites W2039659007 @default.
• W2014283432 cites W2039882796 @default.
• W2014283432 cites W2043745529 @default.
• W2014283432 cites W2047916845 @default.
• W2014283432 cites W2047991609 @default.
• W2014283432 cites W2056833001 @default.
• W2014283432 cites W2058404050 @default.
• W2014283432 cites W2059668389 @default.
• W2014283432 cites W2060459591 @default.
• W2014283432 cites W2061761194 @default.
• W2014283432 cites W2063942008 @default.
• W2014283432 cites W2064117855 @default.
• W2014283432 cites W2068555859 @default.
• W2014283432 cites W2068702879 @default.
• W2014283432 cites W2071065596 @default.
• W2014283432 cites W2074845194 @default.
• W2014283432 cites W2077163152 @default.
• W2014283432 cites W2077765377 @default.
• W2014283432 cites W2078945968 @default.
• W2014283432 cites W2079949733 @default.
• W2014283432 cites W2090133124 @default.
• W2014283432 cites W2090162541 @default.
• W2014283432 cites W2093881079 @default.
• W2014283432 cites W2094253447 @default.
• W2014283432 cites W2096850955 @default.
• W2014283432 cites W2099833780 @default.
• W2014283432 cites W2102126633 @default.
• W2014283432 cites W2104943753 @default.
• W2014283432 cites W2105860922 @default.
• W2014283432 cites W2108063837 @default.
• W2014283432 cites W2117565708 @default.
• W2014283432 cites W2118187866 @default.
• W2014283432 cites W2118962488 @default.
• W2014283432 cites W2121609307 @default.
• W2014283432 cites W2125860227 @default.
• W2014283432 cites W2130934825 @default.
• W2014283432 cites W2135406512 @default.
• W2014283432 cites W2135933358 @default.
• W2014283432 cites W2136006075 @default.
• W2014283432 cites W2138783699 @default.
• W2014283432 cites W2140140747 @default.
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• W2014283432 cites W2158748180 @default.
• W2014283432 cites W2162765748 @default.
• W2014283432 cites W2165999121 @default.
• W2014283432 cites W2168555181 @default.
• W2014283432 cites W2325952732 @default.
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• W2014283432 doi "https://doi.org/10.1002/jbmr.41" @default.
• W2014283432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3154000" @default.
• W2014283432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20200957" @default.
• W2014283432 hasPublicationYear "2010" @default.
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