FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014283537> ?p ?o ?g. }

• W2014283537 endingPage "1314" @default.
• W2014283537 startingPage "1308" @default.
• W2014283537 abstract "Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic elimination of many drugs and potentially associated drug-drug interactions. The gemfibrozil-statin interaction was studied at the level of active hepatic uptake as a model for such drug-drug interactions. Active, temperature-dependent uptake of fluvastatin into primary human hepatocytes was shown. Multiple transporters are involved in this uptake as Chinese hamster ovary or HEK293 cells expressing either OATP1B1 (K(m) = 1.4-3.5 microM), OATP2B1 (K(m) = 0.7-0.8 microM), or OATP1B3 showed significant fluvastatin uptake relative to control cells. For OATP1B1 the inhibition by gemfibrozil was substrate-dependent as the transport of fluvastatin (IC(50) of 63 microM), pravastatin, simvastatin, and taurocholate was inhibited by gemfibrozil, whereas the transport of estrone-3-sulfate and troglitazone sulfate (both used at 3 microM) was not affected. The OATP1B1- but not OATP2B1-mediated transport of estrone-3-sulfate displayed biphasic saturation kinetics, with two distinct affinity components for estrone-3-sulfate (0.23 and 45 microM). Only the high-affinity component was inhibited by gemfibrozil. Recombinant OATP1B1-, OATP2B1-, and OATP1B3-mediated fluvastatin transport was inhibited to 97, 70, and 62% by gemfibrozil (200 microM), respectively, whereas only a small inhibitory effect by gemfibrozil (200 microM) on fluvastatin uptake into primary human hepatocytes was observed (27% inhibition). The results indicate that the in vitro engineered systems can not always predict the behavior in more complex systems such as freshly isolated primary hepatocytes. Therefore, selection of substrate, substrate concentration, and in vitro transport system are critical for the conduct of in vitro interaction studies involving individual liver OATP carriers." @default.
• W2014283537 created "2016-06-24" @default.
• W2014283537 creator A5000029600 @default.
• W2014283537 creator A5001393185 @default.
• W2014283537 creator A5015581560 @default.
• W2014283537 creator A5057132218 @default.
• W2014283537 date "2007-04-30" @default.
• W2014283537 modified "2023-10-18" @default.
• W2014283537 title "Substrate-Dependent Drug-Drug Interactions between Gemfibrozil, Fluvastatin and Other Organic Anion-Transporting Peptide (OATP) Substrates on OATP1B1, OATP2B1, and OATP1B3" @default.
• W2014283537 cites W170029080 @default.
• W2014283537 cites W1964471078 @default.
• W2014283537 cites W1966846971 @default.
• W2014283537 cites W1971901938 @default.
• W2014283537 cites W1973774087 @default.
• W2014283537 cites W2005518854 @default.
• W2014283537 cites W2008077160 @default.
• W2014283537 cites W2010241890 @default.
• W2014283537 cites W2028444358 @default.
• W2014283537 cites W2030873577 @default.
• W2014283537 cites W2036682576 @default.
• W2014283537 cites W2040716003 @default.
• W2014283537 cites W2048593300 @default.
• W2014283537 cites W2051009834 @default.
• W2014283537 cites W2076385318 @default.
• W2014283537 cites W2085448380 @default.
• W2014283537 cites W2088928036 @default.
• W2014283537 cites W2092943664 @default.
• W2014283537 cites W2098274747 @default.
• W2014283537 cites W2107260421 @default.
• W2014283537 cites W2116248545 @default.
• W2014283537 cites W2133282432 @default.
• W2014283537 cites W2144438205 @default.
• W2014283537 cites W2145804243 @default.
• W2014283537 cites W2158607621 @default.
• W2014283537 cites W2163711771 @default.
• W2014283537 cites W2302091022 @default.
• W2014283537 doi "https://doi.org/10.1124/dmd.106.012930" @default.
• W2014283537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17470528" @default.
• W2014283537 hasPublicationYear "2007" @default.
• W2014283537 type Work @default.
• W2014283537 sameAs 2014283537 @default.
• W2014283537 citedByCount "260" @default.
• W2014283537 countsByYear W20142835372012 @default.
• W2014283537 countsByYear W20142835372013 @default.
• W2014283537 countsByYear W20142835372014 @default.
• W2014283537 countsByYear W20142835372015 @default.
• W2014283537 countsByYear W20142835372016 @default.
• W2014283537 countsByYear W20142835372017 @default.
• W2014283537 countsByYear W20142835372018 @default.
• W2014283537 countsByYear W20142835372019 @default.
• W2014283537 countsByYear W20142835372020 @default.
• W2014283537 countsByYear W20142835372021 @default.
• W2014283537 countsByYear W20142835372022 @default.
• W2014283537 countsByYear W20142835372023 @default.
• W2014283537 crossrefType "journal-article" @default.
• W2014283537 hasAuthorship W2014283537A5000029600 @default.
• W2014283537 hasAuthorship W2014283537A5001393185 @default.
• W2014283537 hasAuthorship W2014283537A5015581560 @default.
• W2014283537 hasAuthorship W2014283537A5057132218 @default.
• W2014283537 hasConcept C104317684 @default.
• W2014283537 hasConcept C123584848 @default.
• W2014283537 hasConcept C149011108 @default.
• W2014283537 hasConcept C170493617 @default.
• W2014283537 hasConcept C185592680 @default.
• W2014283537 hasConcept C187345961 @default.
• W2014283537 hasConcept C2776329913 @default.
• W2014283537 hasConcept C2776678969 @default.
• W2014283537 hasConcept C2778150266 @default.
• W2014283537 hasConcept C2778163477 @default.
• W2014283537 hasConcept C2778417548 @default.
• W2014283537 hasConcept C2778656385 @default.
• W2014283537 hasConcept C2778670441 @default.
• W2014283537 hasConcept C2779149875 @default.
• W2014283537 hasConcept C2779519902 @default.
• W2014283537 hasConcept C55493867 @default.
• W2014283537 hasConcept C71315377 @default.
• W2014283537 hasConcept C86803240 @default.
• W2014283537 hasConcept C98274493 @default.
• W2014283537 hasConceptScore W2014283537C104317684 @default.
• W2014283537 hasConceptScore W2014283537C123584848 @default.
• W2014283537 hasConceptScore W2014283537C149011108 @default.
• W2014283537 hasConceptScore W2014283537C170493617 @default.
• W2014283537 hasConceptScore W2014283537C185592680 @default.
• W2014283537 hasConceptScore W2014283537C187345961 @default.
• W2014283537 hasConceptScore W2014283537C2776329913 @default.
• W2014283537 hasConceptScore W2014283537C2776678969 @default.
• W2014283537 hasConceptScore W2014283537C2778150266 @default.
• W2014283537 hasConceptScore W2014283537C2778163477 @default.
• W2014283537 hasConceptScore W2014283537C2778417548 @default.
• W2014283537 hasConceptScore W2014283537C2778656385 @default.
• W2014283537 hasConceptScore W2014283537C2778670441 @default.
• W2014283537 hasConceptScore W2014283537C2779149875 @default.
• W2014283537 hasConceptScore W2014283537C2779519902 @default.
• W2014283537 hasConceptScore W2014283537C55493867 @default.
• W2014283537 hasConceptScore W2014283537C71315377 @default.
• W2014283537 hasConceptScore W2014283537C86803240 @default.
• W2014283537 hasConceptScore W2014283537C98274493 @default.
• W2014283537 hasIssue "8" @default.

• next